Panthers vs. Senators NHL Predictions, Picks and Odds - Oct. 21
21 October 2026

Carter Verhaeghe will be coming off a hat trick when his Florida Panthers visit the Ottawa Senators on Wednesday at 7:30 p.m. ET. The Senators are slight underdogs, at -108, and the Panthers are -112.
Florida won 8-3 at home its last time out on Oct. 17 against the Seattle Kraken. Verhaeghe (three goals) and Sam Bennett (three goals) were among the three Panthers players who collected three points each.
Ottawa played on the road in its last game on Oct. 17, and lost 3-1 against the Philadelphia Flyers. Three Senators players recorded one point each in that outing, including Claude Giroux (one assist) and Tim Stutzle (one assist).
Before watching this matchup, here is a look at which squad we think will come out on top in Wednesday's action on the ice.
Bet now on FanDuel Sportsbook!Panthers vs. Senators Predictions & Pick
For predictions on the upcoming contest between the Florida Panthers and Ottawa Senators, computer-calculated moneyline, over/under, and score predictions are below, based on data from Dunkel Index.
- Prediction: Senators 4 - Panthers 3
- Pick OU:
Over 5.5
(Dunkel projecting 7 goals)
Pick with the best in the business! Get free picks for every game, every week at the Dunkel Index.
Panthers vs. Senators Moneylines
Grab a look below at the latest moneylines for the Panthers-Senators matchup.
- Favorite: Panthers (-112)
- Underdog: Senators (-108)
Panthers Betting Insights
- The Panthers are 3-3 when favored on the moneyline this season.
- Florida is 3-3 (victorious in 50.0% of its games) when it has played with moneyline odds of -112 or shorter.
- The implied moneyline probability in this game says the Panthers have a 52.8% chance to win.
- In four of nine matches this season, Florida and its opponent have combined for more than 5.5 goals.
Senators Betting Insights
- This season the Senators have been an underdog four times, and won two of those games.
- Ottawa has entered four games this season as an underdog by -108 or more and is 2-2 in those contests.
- Oddsmakers have implied, given the moneyline set for this matchup, that the Senators have a 51.9% chance to win.
- Ottawa and its opponent have combined for more than 5.5 goals just twice this season.
Panthers Key Stats
- Florida ranks 14th in the NHL with 30 goals scored (3.3 per game).
- Defensively, the Panthers are one of the stingiest squads in league play, giving up 25 total goals (2.8 per game) to rank eighth.
- Its +5 goal differential ranks 12th in the league.
- The nine power-play goals the Panthers have recorded this season are fifth-best in the NHL (on 43 power-play chances).
- Florida ranks 17th in the league with a 20.93% power-play conversion rate.
- Florida kills 80.56% of opponent power plays, the 13th-ranked penalty-kill percentage in the league.
- Florida wins 46.2% of its faceoffs (27th in NHL).
- The Panthers shoot 11.4% as a team (17th in the league).
Senators Key Stats
- With 22 goals (2.4 per game), Ottawa has the league's 25th-ranked offense.
- The Senators allow 2.6 goals per game (23 in total), the fifth-fewest in the NHL.
- With a goal differential of -1, the team is 18th in the league.
- The Senators have five power-play goals (on 39 chances), 20th in the NHL.
- Ottawa scores on 12.82% of its power plays, No. 29 in the NHL.
- In terms of shorthanded goal, the Senators have one.
- At 79.41%, Ottawa has the 16th-ranked penalty-kill percentage in the league.
- At 51.4%, Ottawa has the NHL's 13th-ranked faceoff win percentage.
- With a shooting percentage of 10.6%, the Senators are 21st in the league.
