NFL Predictions & Betting Odds - Week 4
29 September 2026
The Denver Broncos versus the San Francisco 49ers is a game to see on a Week 4 NFL slate that features a lot of thrilling contests.
We've got you sorted out with a fast summary on every NFL tilt this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Continue scrolling for the key information.
Bet now on FanDuel Sportsbook!Week 4 Games, Betting Info, and Predictions
There are 16 games on the pro football schedule this week. Here's a peek at each matchup:
Pittsburgh Steelers (2-2) at Cleveland Browns (3-1)
- Game Time: 8:15 p.m. ET | Thursday, October 1, 2026
- Venue: Huntington Bank Field (Cleveland, Ohio)
- Total: 38.5
- Spread: Steelers (-2.5)
- Moneyline: Steelers (-148), Browns (+124)
Dunkel Index predictions:
- Over/Under: Over (38.5)
- ATS: Browns (+2.5)
- Score Prediction: Browns 21, Steelers 19
Indianapolis Colts (2-2) at Washington Commanders (1-3)
- Game Time: 9:30 a.m. ET | Sunday, October 4, 2026
- Venue: Tottenham Hotspur Stadium (London, England)
- Total: 46.5
- Spread: Colts (-5.5)
- Moneyline: Colts (-218), Commanders (+180)
Dunkel Index predictions:
- Over/Under: Over (46.5)
- ATS: Commanders (+5.5)
- Score Prediction: Colts 29, Commanders 26
New England Patriots (2-2) at Buffalo Bills (3-1)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: New Highmark Stadium (Orchard Park, New York)
- Total: 49.5
- Spread: Bills (-7)
- Moneyline: Bills (-345), Patriots (+275)
Dunkel Index predictions:
- Over/Under: Under (49.5)
- ATS: Patriots (+7)
- Score Prediction: Bills 23, Patriots 21
New York Jets (1-3) at Chicago Bears (3-1)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: Soldier Field (Chicago, Illinois)
- Total: 43.5
- Spread: Bears (-3.5)
- Moneyline: Bears (-192), Jets (+160)
Dunkel Index predictions:
- Over/Under: Over (43.5)
- ATS: Bears (-3.5)
- Score Prediction: Bears 29, Jets 16
Jacksonville Jaguars (3-1) at Cincinnati Bengals (2-2)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: Paycor Stadium (Cincinnati, Ohio)
- Total: 51.5
- Spread: Bengals (-2.5)
- Moneyline: Bengals (-148), Jaguars (+124)
Dunkel Index predictions:
- Over/Under: Under (51.5)
- ATS: Jaguars (+2.5)
- Score Prediction: Jaguars 24, Bengals 19
Dallas Cowboys (2-2) at Houston Texans (0-4)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: NRG Stadium (Houston, Texas)
- Total: 48.5
- Spread: Texans (-3)
- Moneyline: Texans (-155), Cowboys (+130)
Dunkel Index predictions:
- Over/Under: Over (48.5)
- ATS: Texans (-3)
- Score Prediction: Texans 28, Cowboys 22
Arizona Cardinals (1-3) at New York Giants (3-1)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: MetLife Stadium (East Rutherford, New Jersey)
- Total: 44.5
- Spread: Cardinals (-2.5)
- Moneyline: Cardinals (-135), Giants (+114)
Dunkel Index predictions:
- Over/Under: Under (44.5)
- ATS: Giants (+2.5)
- Score Prediction: Giants 22, Cardinals 19
Los Angeles Rams (2-2) at Philadelphia Eagles (2-2)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: Lincoln Financial Field (Philadelphia, Pennsylvania)
- Total: 43.5
- Spread: Rams (-4.5)
- Moneyline: Rams (-198), Eagles (+164)
Dunkel Index predictions:
- Over/Under: Under (43.5)
- ATS: Eagles (+4.5)
- Score Prediction: Rams 21, Eagles 20
Green Bay Packers (2-2) at Tampa Bay Buccaneers (0-4)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: Raymond James Stadium (Tampa, Florida)
- Total: 39.5
- Spread: Packers (-3)
- Moneyline: Packers (-155), Buccaneers (+130)
Dunkel Index predictions:
- Over/Under: Over (39.5)
- ATS: Buccaneers (+3)
- Score Prediction: Buccaneers 27, Packers 21
Tennessee Titans (0-4) at Baltimore Ravens (3-1)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: M&T Bank Stadium (Baltimore, Maryland)
- Total: 42.5
- Spread: Ravens (-11.5)
- Moneyline: Ravens (-800), Titans (+550)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Ravens (-11.5)
- Score Prediction: Ravens 29, Titans 16
Miami Dolphins (0-4) at Minnesota Vikings (4-0)
- Game Time: 4:05 p.m. ET | Sunday, October 4, 2026
- Venue: U.S. Bank Stadium (Minneapolis, Minnesota)
- Total: 38.5
- Spread: Vikings (-9.5)
- Moneyline: Vikings (-535), Dolphins (+400)
Dunkel Index predictions:
- Over/Under: Over (38.5)
- ATS: Dolphins (+9.5)
- Score Prediction: Vikings 24, Dolphins 15
Los Angeles Chargers (0-4) at Seattle Seahawks (3-1)
- Game Time: 4:25 p.m. ET | Sunday, October 4, 2026
- Venue: Lumen Field (Seattle, Washington)
- Total: 42.5
- Spread: Seahawks (-7)
- Moneyline: Seahawks (-360), Chargers (+285)
Dunkel Index predictions:
- Over/Under: Under (42.5)
- ATS: Seahawks (-7)
- Score Prediction: Seahawks 26, Chargers 15
Kansas City Chiefs (4-0) at Las Vegas Raiders (3-1)
- Game Time: 4:25 p.m. ET | Sunday, October 4, 2026
- Venue: Allegiant Stadium (Paradise, Nevada)
- Total: 48.5
- Spread: Chiefs (-5.5)
- Moneyline: Chiefs (-225), Raiders (+185)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: Raiders (+5.5)
- Score Prediction: Chiefs 24, Raiders 23
Denver Broncos (2-2) at San Francisco 49ers (4-0)
- Game Time: 4:25 p.m. ET | Sunday, October 4, 2026
- Venue: Levi's Stadium (Santa Clara, California)
- Total: 48.5
- Spread: 49ers (-3)
- Moneyline: 49ers (-162), Broncos (+136)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: 49ers (-3)
- Score Prediction: 49ers 26, Broncos 20
Detroit Lions (2-2) at Carolina Panthers (2-2)
- Game Time: 8:20 p.m. ET | Sunday, October 4, 2026
- Venue: Bank of America Stadium (Charlotte, North Carolina)
- Total: 52.5
- Spread: Lions (-3.5)
- Moneyline: Lions (-218), Panthers (+180)
Dunkel Index predictions:
- Over/Under: Over (52.5)
- ATS: Panthers (+3.5)
- Score Prediction: Panthers 31, Lions 29
Atlanta Falcons (1-2) at New Orleans Saints (1-2)
- Game Time: 8:15 p.m. ET | Monday, October 5, 2026
- Venue: Caesars Superdome (New Orleans, Louisiana)
- Total: 48.5
- Spread: Saints (-1.5)
- Moneyline: Saints (-122), Falcons (+102)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: Saints (-1.5)
- Score Prediction: Saints 26, Falcons 21
