NFL Predictions & Betting Odds - Week 4
29 September 2026
The NFL lineup in Week 4 should provide some fireworks. The contests include the Denver Broncos squaring off against the San Francisco 49ers at Levi's Stadium.
We've got you sorted out with a quick summary on every NFL contest this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Continue reading for the key information.
Bet now on FanDuel Sportsbook!Week 4 Games, Betting Info, and Predictions
There are 16 games on the NFL slate this week. Below is a peek at each matchup:
Pittsburgh Steelers (2-1) at Cleveland Browns (2-1)
- Game Time: 8:15 p.m. ET | Thursday, October 1, 2026
- Venue: Huntington Bank Field (Cleveland, Ohio)
- Total: 38.5
- Spread: Steelers (-2.5)
- Moneyline: Steelers (-148), Browns (+124)
Dunkel Index predictions:
- Over/Under: Over (38.5)
- ATS: Browns (+2.5)
- Score Prediction: Browns 21, Steelers 19
Indianapolis Colts (1-2) at Washington Commanders (1-2)
- Game Time: 9:30 a.m. ET | Sunday, October 4, 2026
- Venue: Tottenham Hotspur Stadium (London, England)
- Total: 47.5
- Spread: Colts (-3.5)
- Moneyline: Colts (-180), Commanders (+150)
Dunkel Index predictions:
- Over/Under: Over (47.5)
- ATS: Colts (-3.5)
- Score Prediction: Colts 29, Commanders 26
Tennessee Titans (0-3) at Baltimore Ravens (2-1)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: M&T Bank Stadium (Baltimore, Maryland)
- Total: 43.5
- Spread: Ravens (-11.5)
- Moneyline: Ravens (-752), Titans (+525)
Dunkel Index predictions:
- Over/Under: Over (43.5)
- ATS: Ravens (-11.5)
- Score Prediction: Ravens 28, Titans 16
Los Angeles Rams (1-2) at Philadelphia Eagles (2-1)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: Lincoln Financial Field (Philadelphia, Pennsylvania)
- Total: 44.5
- Spread: Rams (-3)
- Moneyline: Rams (-162), Eagles (+136)
Dunkel Index predictions:
- Over/Under: Under (44.5)
- ATS: Eagles (+3)
- Score Prediction: Rams 21, Eagles 20
Dallas Cowboys (1-2) at Houston Texans (0-3)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: NRG Stadium (Houston, Texas)
- Total: 48.5
- Spread: Texans (-2.5)
- Moneyline: Texans (-142), Cowboys (+120)
Dunkel Index predictions:
- Over/Under: Over (48.5)
- ATS: Texans (-2.5)
- Score Prediction: Texans 27, Cowboys 22
New England Patriots (1-2) at Buffalo Bills (3-0)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: New Highmark Stadium (Orchard Park, New York)
- Total: 48.5
- Spread: Bills (-6.5)
- Moneyline: Bills (-298), Patriots (+240)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: Patriots (+6.5)
- Score Prediction: Bills 23, Patriots 21
Arizona Cardinals (1-2) at New York Giants (2-1)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: MetLife Stadium (East Rutherford, New Jersey)
- Total: 44.5
- Spread: Cardinals (-1.5)
- Moneyline: Cardinals (-115), Giants (-105)
Dunkel Index predictions:
- Over/Under: Under (44.5)
- ATS: Giants (+1.5)
- Score Prediction: Giants 22, Cardinals 19
Green Bay Packers (1-2) at Tampa Bay Buccaneers (0-3)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: Raymond James Stadium (Tampa, Florida)
- Total: 39.5
- Spread: Packers (-4.5)
- Moneyline: Packers (-192), Buccaneers (+160)
Dunkel Index predictions:
- Over/Under: Over (39.5)
- ATS: Buccaneers (+4.5)
- Score Prediction: Buccaneers 27, Packers 21
New York Jets (1-2) at Chicago Bears (2-1)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: Soldier Field (Chicago, Illinois)
- Total: 42.5
- Spread: Bears (-3.5)
- Moneyline: Bears (-170), Jets (+142)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Bears (-3.5)
- Score Prediction: Bears 29, Jets 16
Jacksonville Jaguars (2-1) at Cincinnati Bengals (2-1)
- Game Time: 1 p.m. ET | Sunday, October 4, 2026
- Venue: Paycor Stadium (Cincinnati, Ohio)
- Total: 51.5
- Spread: Bengals (-2.5)
- Moneyline: Bengals (-148), Jaguars (+124)
Dunkel Index predictions:
- Over/Under: Under (51.5)
- ATS: Jaguars (+2.5)
- Score Prediction: Jaguars 24, Bengals 19
Miami Dolphins (0-3) at Minnesota Vikings (3-0)
- Game Time: 4:05 p.m. ET | Sunday, October 4, 2026
- Venue: U.S. Bank Stadium (Minneapolis, Minnesota)
- Total: 38.5
- Spread: Vikings (-10.5)
- Moneyline: Vikings (-699), Dolphins (+500)
Dunkel Index predictions:
- Over/Under: Over (38.5)
- ATS: Dolphins (+10.5)
- Score Prediction: Vikings 24, Dolphins 15
Kansas City Chiefs (3-0) at Las Vegas Raiders (3-0)
- Game Time: 4:25 p.m. ET | Sunday, October 4, 2026
- Venue: Allegiant Stadium (Paradise, Nevada)
- Total: 48.5
- Spread: Chiefs (-4.5)
- Moneyline: Chiefs (-225), Raiders (+185)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: Raiders (+4.5)
- Score Prediction: Raiders 24, Chiefs 23
Los Angeles Chargers (0-3) at Seattle Seahawks (2-1)
- Game Time: 4:25 p.m. ET | Sunday, October 4, 2026
- Venue: Lumen Field (Seattle, Washington)
- Total: 43.5
- Spread: Seahawks (-7.5)
- Moneyline: Seahawks (-355), Chargers (+280)
Dunkel Index predictions:
- Over/Under: Under (43.5)
- ATS: Seahawks (-7.5)
- Score Prediction: Seahawks 26, Chargers 15
Denver Broncos (2-1) at San Francisco 49ers (3-0)
- Game Time: 4:25 p.m. ET | Sunday, October 4, 2026
- Venue: Levi's Stadium (Santa Clara, California)
- Total: 46.5
- Spread: 49ers (-2.5)
- Moneyline: 49ers (-155), Broncos (+130)
Dunkel Index predictions:
- Over/Under: Under (46.5)
- ATS: 49ers (-2.5)
- Score Prediction: 49ers 26, Broncos 20
Detroit Lions (2-1) at Carolina Panthers (1-2)
- Game Time: 8:20 p.m. ET | Sunday, October 4, 2026
- Venue: Bank of America Stadium (Charlotte, North Carolina)
- Total: 50.5
- Spread: Lions (-3.5)
- Moneyline: Lions (-185), Panthers (+154)
Dunkel Index predictions:
- Over/Under: Over (50.5)
- ATS: Panthers (+3.5)
- Score Prediction: Panthers 32, Lions 28
Atlanta Falcons (1-2) at New Orleans Saints (1-2)
- Game Time: 8:15 p.m. ET | Monday, October 5, 2026
- Venue: Caesars Superdome (New Orleans, Louisiana)
- Total: 48.5
- Spread: Saints (-2.5)
- Moneyline: Saints (-155), Falcons (+130)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: Saints (-2.5)
- Score Prediction: Saints 27, Falcons 20
