NFL Predictions & Betting Odds - Week 3
22 September 2026
The Week 3 NFL schedule should have plenty of excitement on the field. Among those contests is the New England Patriots squaring off against the Jacksonville Jaguars.
We've got your back with a fast summary on every NFL game this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Keep reading for the details.
Bet now on FanDuel Sportsbook!Week 3 Games, Betting Info, and Predictions
There are 16 games on the pro football schedule this week. Here's a look at each one:
Atlanta Falcons (1-2) at Green Bay Packers (1-2)
- Game Time: 8:15 p.m. ET | Thursday, September 24, 2026
- Venue: Lambeau Field (Green Bay, Wisconsin)
- Total: 43.5
- Spread: Packers (-4.5)
- Moneyline: Packers (-238), Falcons (+195)
Dunkel Index predictions:
- Over/Under: Under (43.5)
- ATS: Packers (-4.5)
- Score Prediction: Packers 31, Falcons 11
Tennessee Titans (0-3) at New York Giants (2-1)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: MetLife Stadium (East Rutherford, New Jersey)
- Total: 37.5
- Spread: Giants (-2.5)
- Moneyline: Giants (-130), Titans (+110)
Dunkel Index predictions:
- Over/Under: Over (37.5)
- ATS: Giants (-2.5)
- Score Prediction: Giants 24, Titans 15
New England Patriots (1-2) at Jacksonville Jaguars (2-1)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: EverBank Stadium (Jacksonville, Florida)
- Total: 46.5
- Spread: Jaguars (-3)
- Moneyline: Jaguars (-162), Patriots (+136)
Dunkel Index predictions:
- Over/Under: Under (46.5)
- ATS: Patriots (+3)
- Score Prediction: Patriots 17, Jaguars 13
Houston Texans (0-3) at Indianapolis Colts (1-2)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Lucas Oil Stadium (Indianapolis, Indiana)
- Total: 42.5
- Spread: Texans (-1.5)
- Moneyline: Texans (-125), Colts (+105)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Colts (+1.5)
- Score Prediction: Colts 30, Texans 25
Kansas City Chiefs (3-0) at Miami Dolphins (0-3)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Hard Rock Stadium (Miami Gardens, Florida)
- Total: 45.5
- Spread: Chiefs (-9.5)
- Moneyline: Chiefs (-599), Dolphins (+440)
Dunkel Index predictions:
- Over/Under: Over (45.5)
- ATS: Dolphins (+9.5)
- Score Prediction: Dolphins 25, Chiefs 24
Los Angeles Chargers (0-3) at Buffalo Bills (3-0)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: New Highmark Stadium (Orchard Park, New York)
- Total: 50.5
- Spread: Bills (-7)
- Moneyline: Bills (-325), Chargers (+260)
Dunkel Index predictions:
- Over/Under: Over (50.5)
- ATS: Bills (-7)
- Score Prediction: Bills 31, Chargers 24
New York Jets (1-2) at Detroit Lions (2-1)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Ford Field (Detroit, Michigan)
- Total: 49.5
- Spread: Lions (-7)
- Moneyline: Lions (-325), Jets (+260)
Dunkel Index predictions:
- Over/Under: Over (49.5)
- ATS: Lions (-7)
- Score Prediction: Lions 32, Jets 19
Cincinnati Bengals (2-1) at Pittsburgh Steelers (2-1)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Acrisure Stadium (Pittsburgh, Pennsylvania)
- Total: 42.5
- Spread: Bengals (-3.5)
- Moneyline: Bengals (-180), Steelers (+150)
Dunkel Index predictions:
- Over/Under: Under (42.5)
- ATS: Steelers (+3.5)
- Score Prediction: Steelers 21, Bengals 14
Carolina Panthers (1-2) at Cleveland Browns (2-1)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Huntington Bank Field (Cleveland, Ohio)
- Total: 42.5
- Spread: Panthers (-2.5)
- Moneyline: Panthers (-135), Browns (+114)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Panthers (-2.5)
- Score Prediction: Panthers 31, Browns 24
Seattle Seahawks (2-1) at Washington Commanders (1-2)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Northwest Stadium (Landover, Maryland)
- Total: 40.5
- Spread: Seahawks (-8.5)
- Moneyline: Seahawks (-410), Commanders (+320)
Dunkel Index predictions:
- Over/Under: Over (40.5)
- ATS: Seahawks (-8.5)
- Score Prediction: Seahawks 31, Commanders 10
Arizona Cardinals (1-2) at San Francisco 49ers (3-0)
- Game Time: 4:05 p.m. ET | Sunday, September 27, 2026
- Venue: Levi's Stadium (Santa Clara, California)
- Total: 48.5
- Spread: 49ers (-7.5)
- Moneyline: 49ers (-395), Cardinals (+310)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: 49ers (-7.5)
- Score Prediction: 49ers 28, Cardinals 12
Minnesota Vikings (3-0) at Tampa Bay Buccaneers (0-3)
- Game Time: 4:05 p.m. ET | Sunday, September 27, 2026
- Venue: Raymond James Stadium (Tampa, Florida)
- Total: 42.5
- Spread: Vikings (-1.5)
- Moneyline: Vikings (-115), Buccaneers (-105)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Vikings (-1.5)
- Score Prediction: Vikings 25, Buccaneers 19
Las Vegas Raiders (3-0) at New Orleans Saints (1-2)
- Game Time: 4:25 p.m. ET | Sunday, September 27, 2026
- Venue: Caesars Superdome (New Orleans, Louisiana)
- Total: 44.5
- Spread: Saints (-3.5)
- Moneyline: Saints (-192), Raiders (+160)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Saints (-3.5)
- Score Prediction: Saints 27, Raiders 19
Baltimore Ravens (2-1) at Dallas Cowboys (1-2)
- Game Time: 4:25 p.m. ET | Sunday, September 27, 2026
- Venue: Maracanã Stadium (Rio de Janeiro, Brazil)
- Total: 53.5
- Spread: Ravens (-3.5)
- Moneyline: Ravens (-166), Cowboys (+140)
Dunkel Index predictions:
- Over/Under: Under (53.5)
- ATS: Ravens (-3.5)
- Score Prediction: Ravens 29, Cowboys 23
Los Angeles Rams (1-2) at Denver Broncos (2-1)
- Game Time: 8:20 p.m. ET | Sunday, September 27, 2026
- Venue: Empower Field at Mile High (Denver, Colorado)
- Total: 44.5
- Spread: Rams (-1.5)
- Moneyline: Rams (-115), Broncos (-105)
Dunkel Index predictions:
- Over/Under: Under (44.5)
- ATS: Broncos (+1.5)
- Score Prediction: Broncos 19, Rams 17
Philadelphia Eagles (2-0) at Chicago Bears (1-1)
- Game Time: 8:15 p.m. ET | Monday, September 28, 2026
- Venue: Soldier Field (Chicago, Illinois)
- Total: 42.5
- Spread: Eagles (-3.5)
- Moneyline: Eagles (-185), Bears (+154)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Bears (+3.5)
- Score Prediction: Bears 28, Eagles 22
