NFL Predictions & Betting Odds - Week 3
22 September 2026
The Week 3 NFL slate has plenty of quality competition in store. Among those games is the New England Patriots playing the Jacksonville Jaguars.
We've got you covered with a quick summary on every NFL contest this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Keep scrolling for the details.
Bet now on FanDuel Sportsbook!Week 3 Games, Betting Info, and Predictions
There are 16 games on the NFL docket this week. Here's a glance at each matchup:
Atlanta Falcons (0-2) at Green Bay Packers (1-1)
- Game Time: 8:15 p.m. ET | Thursday, September 24, 2026
- Venue: Lambeau Field (Green Bay, Wisconsin)
- Total: 43.5
- Spread: Packers (-5.5)
- Moneyline: Packers (-270), Falcons (+220)
Dunkel Index predictions:
- Over/Under: Under (43.5)
- ATS: Packers (-5.5)
- Score Prediction: Packers 31, Falcons 11
Los Angeles Chargers (0-2) at Buffalo Bills (2-0)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: New Highmark Stadium (Orchard Park, New York)
- Total: 50.5
- Spread: Bills (-7.5)
- Moneyline: Bills (-345), Chargers (+275)
Dunkel Index predictions:
- Over/Under: Over (50.5)
- ATS: Bills (-7.5)
- Score Prediction: Bills 36, Chargers 19
Carolina Panthers (1-1) at Cleveland Browns (1-1)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Huntington Bank Field (Cleveland, Ohio)
- Total: 42.5
- Spread: Panthers (-2.5)
- Moneyline: Panthers (-148), Browns (+124)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Panthers (-2.5)
- Score Prediction: Panthers 32, Browns 23
Seattle Seahawks (2-0) at Washington Commanders (0-2)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Northwest Stadium (Landover, Maryland)
- Total: 40.5
- Spread: Seahawks (-7)
- Moneyline: Seahawks (-298), Commanders (+240)
Dunkel Index predictions:
- Over/Under: Over (40.5)
- ATS: Seahawks (-7)
- Score Prediction: Seahawks 36, Commanders 5
New England Patriots (1-1) at Jacksonville Jaguars (1-1)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: EverBank Stadium (Jacksonville, Florida)
- Total: 45.5
- Spread: Jaguars (-3)
- Moneyline: Jaguars (-155), Patriots (+130)
Dunkel Index predictions:
- Over/Under: Under (45.5)
- ATS: Patriots (+3)
- Score Prediction: Patriots 16, Jaguars 15
Tennessee Titans (0-2) at New York Giants (1-1)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: MetLife Stadium (East Rutherford, New Jersey)
- Total: 39.5
- Spread: Giants (-2.5)
- Moneyline: Giants (-135), Titans (+114)
Dunkel Index predictions:
- Over/Under: Over (39.5)
- ATS: Giants (-2.5)
- Score Prediction: Giants 24, Titans 15
Houston Texans (0-2) at Indianapolis Colts (0-2)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Lucas Oil Stadium (Indianapolis, Indiana)
- Total: 42.5
- Spread: Texans (-2.5)
- Moneyline: Texans (-148), Colts (+124)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Colts (+2.5)
- Score Prediction: Colts 31, Texans 24
Cincinnati Bengals (2-0) at Pittsburgh Steelers (1-1)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Acrisure Stadium (Pittsburgh, Pennsylvania)
- Total: 42.5
- Spread: Bengals (-4.5)
- Moneyline: Bengals (-192), Steelers (+160)
Dunkel Index predictions:
- Over/Under: Under (42.5)
- ATS: Steelers (+4.5)
- Score Prediction: Steelers 18, Bengals 17
Kansas City Chiefs (2-0) at Miami Dolphins (0-2)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Hard Rock Stadium (Miami Gardens, Florida)
- Total: 46.5
- Spread: Chiefs (-11.5)
- Moneyline: Chiefs (-901), Dolphins (+600)
Dunkel Index predictions:
- Over/Under: Over (46.5)
- ATS: Dolphins (+11.5)
- Score Prediction: Chiefs 26, Dolphins 22
New York Jets (1-1) at Detroit Lions (1-1)
- Game Time: 1 p.m. ET | Sunday, September 27, 2026
- Venue: Ford Field (Detroit, Michigan)
- Total: 48.5
- Spread: Lions (-6.5)
- Moneyline: Lions (-305), Jets (+245)
Dunkel Index predictions:
- Over/Under: Over (48.5)
- ATS: Lions (-6.5)
- Score Prediction: Lions 33, Jets 18
Arizona Cardinals (1-1) at San Francisco 49ers (2-0)
- Game Time: 4:05 p.m. ET | Sunday, September 27, 2026
- Venue: Levi's Stadium (Santa Clara, California)
- Total: 48.5
- Spread: 49ers (-8.5)
- Moneyline: 49ers (-485), Cardinals (+370)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: 49ers (-8.5)
- Score Prediction: 49ers 32, Cardinals 8
Minnesota Vikings (2-0) at Tampa Bay Buccaneers (0-2)
- Game Time: 4:05 p.m. ET | Sunday, September 27, 2026
- Venue: Raymond James Stadium (Tampa, Florida)
- Total: 42.5
- Spread: Vikings (-1.5)
- Moneyline: Vikings (-122), Buccaneers (+102)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Vikings (-1.5)
- Score Prediction: Vikings 32, Buccaneers 11
Baltimore Ravens (1-1) at Dallas Cowboys (1-1)
- Game Time: 4:25 p.m. ET | Sunday, September 27, 2026
- Venue: Maracanã Stadium (Rio de Janeiro, Brazil)
- Total: 52.5
- Spread: Ravens (-3.5)
- Moneyline: Ravens (-180), Cowboys (+150)
Dunkel Index predictions:
- Over/Under: Over (52.5)
- ATS: Ravens (-3.5)
- Score Prediction: Ravens 37, Cowboys 16
Las Vegas Raiders (2-0) at New Orleans Saints (1-1)
- Game Time: 4:25 p.m. ET | Sunday, September 27, 2026
- Venue: Caesars Superdome (New Orleans, Louisiana)
- Total: 44.5
- Spread: Saints (-3.5)
- Moneyline: Saints (-185), Raiders (+154)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Saints (-3.5)
- Score Prediction: Saints 31, Raiders 14
Los Angeles Rams (1-1) at Denver Broncos (1-1)
- Game Time: 8:20 p.m. ET | Sunday, September 27, 2026
- Venue: Empower Field at Mile High (Denver, Colorado)
- Total: 45.5
- Spread: Rams (-2.5)
- Moneyline: Rams (-142), Broncos (+120)
Dunkel Index predictions:
- Over/Under: Under (45.5)
- ATS: Rams (-2.5)
- Score Prediction: Rams 20, Broncos 16
Philadelphia Eagles (2-0) at Chicago Bears (1-1)
- Game Time: 8:15 p.m. ET | Monday, September 28, 2026
- Venue: Soldier Field (Chicago, Illinois)
- Total: 41.5
- Spread: Eagles (-4.5)
- Moneyline: Eagles (-225), Bears (+185)
Dunkel Index predictions:
- Over/Under: Over (41.5)
- ATS: Bears (+4.5)
- Score Prediction: Bears 35, Eagles 14
