NFL Predictions & Betting Odds - Week 5
06 October 2026
The matchups in a Week 5 NFL lineup sure to please include the San Francisco 49ers taking on the Seattle Seahawks at Lumen Field.
We've got you sorted out with a fast summary on every NFL contest this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Keep scrolling for the details.
Bet now on FanDuel Sportsbook!Week 5 Games, Betting Info, and Predictions
There are 15 games on the NFL docket this week. Below is a peek at each one:
Tampa Bay Buccaneers (0-4) at Dallas Cowboys (2-2)
- Game Time: 8:15 p.m. ET | Thursday, October 8, 2026
- Venue: AT&T Stadium (Arlington, Texas)
- Total: 47.5
- Spread: Cowboys (-9.5)
- Moneyline: Cowboys (-469), Buccaneers (+360)
Dunkel Index predictions:
- Over/Under: Over (47.5)
- ATS: Buccaneers (+9.5)
- Score Prediction: Cowboys 26, Buccaneers 24
Philadelphia Eagles (2-2) at Jacksonville Jaguars (3-1)
- Game Time: 9:30 a.m. ET | Sunday, October 11, 2026
- Venue: Tottenham Hotspur Stadium (London, England)
- Total: 42.5
- Spread: Jaguars (-7.5)
- Moneyline: Jaguars (-355), Eagles (+280)
Dunkel Index predictions:
- Over/Under: Under (42.5)
- ATS: Eagles (+7.5)
- Score Prediction: Jaguars 24, Eagles 17
Cincinnati Bengals (2-2) at Miami Dolphins (0-4)
- Game Time: 1 p.m. ET | Sunday, October 11, 2026
- Venue: Hard Rock Stadium (Miami Gardens, Florida)
- Total: 42.5
- Spread: Bengals (-6.5)
- Moneyline: Bengals (-325), Dolphins (+260)
Dunkel Index predictions:
- Over/Under: Under (42.5)
- ATS: Dolphins (+6.5)
- Score Prediction: Dolphins 21, Bengals 20
Las Vegas Raiders (3-1) at New England Patriots (2-2)
- Game Time: 1 p.m. ET | Sunday, October 11, 2026
- Venue: Gillette Stadium (Foxborough, Massachusetts)
- Total: 45.5
- Spread: Patriots (-3.5)
- Moneyline: Patriots (-198), Raiders (+164)
Dunkel Index predictions:
- Over/Under: Under (45.5)
- ATS: Patriots (-3.5)
- Score Prediction: Patriots 25, Raiders 17
Minnesota Vikings (4-0) at New Orleans Saints (1-3)
- Game Time: 1 p.m. ET | Sunday, October 11, 2026
- Venue: Caesars Superdome (New Orleans, Louisiana)
- Total: 42.5
- Spread: Vikings (-2.5)
- Moneyline: Vikings (-130), Saints (+110)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Saints (+2.5)
- Score Prediction: Vikings 24, Saints 22
Cleveland Browns (3-1) at New York Jets (1-3)
- Game Time: 1 p.m. ET | Sunday, October 11, 2026
- Venue: MetLife Stadium (East Rutherford, New Jersey)
- Total: 40.5
- Spread: Jets (-2.5)
- Moneyline: Jets (-125), Browns (+105)
Dunkel Index predictions:
- Over/Under: Over (40.5)
- ATS: Browns (+2.5)
- Score Prediction: Browns 22, Jets 21
Indianapolis Colts (2-2) at Pittsburgh Steelers (2-2)
- Game Time: 1 p.m. ET | Sunday, October 11, 2026
- Venue: Acrisure Stadium (Pittsburgh, Pennsylvania)
- Total: 45.5
- Spread: Steelers (-2.5)
- Moneyline: Steelers (-148), Colts (+124)
Dunkel Index predictions:
- Over/Under: Over (45.5)
- ATS: Colts (+2.5)
- Score Prediction: Steelers 24, Colts 22
Houston Texans (0-4) at Tennessee Titans (0-4)
- Game Time: 1 p.m. ET | Sunday, October 11, 2026
- Venue: Nissan Stadium (Nashville, Tennessee)
- Total: 37.5
- Spread: Texans (-7.5)
- Moneyline: Texans (-380), Titans (+300)
Dunkel Index predictions:
- Over/Under: Over (37.5)
- ATS: Titans (+7.5)
- Score Prediction: Texans 22, Titans 20
New York Giants (3-1) at Washington Commanders (1-3)
- Game Time: 1 p.m. ET | Sunday, October 11, 2026
- Venue: Northwest Stadium (Landover, Maryland)
- Total: 42.5
- Spread: Commanders (-3.5)
- Moneyline: Commanders (-175), Giants (+145)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Giants (+3.5)
- Score Prediction: Commanders 24, Giants 23
Chicago Bears (3-1) at Green Bay Packers (2-2)
- Game Time: 1 p.m. ET | Sunday, October 11, 2026
- Venue: Lambeau Field (Green Bay, Wisconsin)
- Total: 45.5
- Spread: Bears (-2.5)
- Moneyline: Bears (-130), Packers (+110)
Dunkel Index predictions:
- Over/Under: Under (45.5)
- ATS: Packers (+2.5)
- Score Prediction: Bears 23, Packers 21
Denver Broncos (2-2) at Los Angeles Chargers (0-4)
- Game Time: 4:05 p.m. ET | Sunday, October 11, 2026
- Venue: SoFi Stadium (Inglewood, California)
- Total: 42.5
- Spread: Broncos (-3.5)
- Moneyline: Broncos (-185), Chargers (+154)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Chargers (+3.5)
- Score Prediction: Broncos 23, Chargers 20
Detroit Lions (2-2) at Arizona Cardinals (1-3)
- Game Time: 4:25 p.m. ET | Sunday, October 11, 2026
- Venue: State Farm Stadium (Glendale, Arizona)
- Total: 54.5
- Spread: Lions (-5.5)
- Moneyline: Lions (-250), Cardinals (+205)
Dunkel Index predictions:
- Over/Under: Over (54.5)
- ATS: Cardinals (+5.5)
- Score Prediction: Cardinals 29, Lions 28
San Francisco 49ers (4-0) at Seattle Seahawks (3-1)
- Game Time: 4:25 p.m. ET | Sunday, October 11, 2026
- Venue: Lumen Field (Seattle, Washington)
- Total: 46.5
- Spread: Seahawks (-2.5)
- Moneyline: Seahawks (-155), 49ers (+130)
Dunkel Index predictions:
- Over/Under: Under (46.5)
- ATS: 49ers (+2.5)
- Score Prediction: Seahawks 24, 49ers 22
Baltimore Ravens (3-1) at Atlanta Falcons (2-2)
- Game Time: 8:20 p.m. ET | Sunday, October 11, 2026
- Venue: Mercedes-Benz Stadium (Atlanta, Georgia)
- Total: 43.5
- Spread: Falcons (-3.5)
- Moneyline: Falcons (-170), Ravens (+142)
Dunkel Index predictions:
- Over/Under: Over (43.5)
- ATS: Ravens (+3.5)
- Score Prediction: Falcons 26, Ravens 24
Buffalo Bills (3-1) at Los Angeles Rams (2-2)
- Game Time: 8:15 p.m. ET | Monday, October 12, 2026
- Venue: SoFi Stadium (Inglewood, California)
- Total: 55.5
- Spread: Rams (-3)
- Moneyline: Rams (-162), Bills (+136)
Dunkel Index predictions:
- Over/Under: Under (55.5)
- ATS: Rams (-3)
- Score Prediction: Rams 28, Bills 22
