Iowa State vs. BYU Dunkel Predictions & Vegas Odds - Feb. 21

The No. 6 Iowa State Cyclones (23-3, 10-3 Big 12) visit the No. 23 BYU Cougars (19-7, 7-6 Big 12) at Marriott Center, starting at 10:30 p.m. ET on Saturday, February 21, 2026. The Cyclones are 2.5-point favorites in the game. The matchup's point total is 154.5.

In its last outing on Monday, Iowa State earned a 70-67 win over Houston. In the victory, Joshua Jefferson led Iowa State with 12 points. BYU is coming off of a 75-68 loss to Arizona in its most recent outing on Wednesday. BYU got a team-high 35 points from AJ Dybantsa in the loss.

Iowa State vs. BYU Odds and Game Time

• When: Saturday, February 21, 2026 at 10:30 p.m. ET
• Where: Marriott Center in Provo, Utah
• Spread favorite: Iowa State -2.5
• Moneyline favorite: Iowa State -164
• Moneyline underdog: BYU +135
• Over/Under: 154.5 points

How to watch Iowa State vs. BYU

• TV Channel: ESPN
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Iowa State vs. BYU

• Iowa State and its opponents have combined to outscore Saturday's over/under (154.5 points) eight times this season.
• In BYU's 26 games this season, 14 finished with more combined points than Saturday's point total of 154.5.
• Together, the two teams combine for 169.5 points per game, 15.0 points more than the over/under of 154.5 for this contest.
• These two teams give up a combined 139.1 points per game, 15.4 points less than this contest's over/under.
• This season the average over/under for Iowa State's games is 148.3 points, 6.2 lower than the over/under of 154.5 points set for this contest.
• A difference of 5.8 points separates the average over/under in BYU's games (160.3 points) and this game's over/under (154.5).

Betting the Spread: Iowa State vs. BYU

• Against the spread, Iowa State is 15-11-0 this year.
• So far this season, the Cyclones have been installed as favorites by a 2.5-point margin or more 25 times and are 14-11 ATS in those games.
• Against the spread, BYU is 11-15-0 this season.
• This year, the Cougars have two ATS wins in four games as an underdog of 2.5 points or more.
• BYU is 10-2 overall, and 4-8 against the spread, at home.
• At home, as a 2.5-point underdog or more, BYU is 4-6 ATS.
• Iowa State is 4-3 against the spread, and 4-3 overall, on the road.
• As 2.5-point favorites or more away from home, Iowa State is 3-3 ATS.

Betting the Moneyline: Iowa State vs. BYU

• This season, Iowa State has won 20 out of the 23 games, or 87%, in which it has been the moneyline favorite.
• This season, the Cyclones have won 18 of their 21 games, or 85.7%, when favored by at least -164 on the moneyline.
• Iowa State has a 62.1% chance to win this game based on the implied probability of the moneyline.
• BYU has been moneyline underdogs in five games this season, however, it has failed to come away with a win in any of those games.
• The Cougars have been listed as an underdog of +135 or more on two occasions this season and lost both games.
• Bookmakers have implied with the moneyline set for this matchup that BYU has a 42.6% chance of pulling out a win.

Dunkel Index Prediction for Iowa State vs. BYU

• Pick ATS: Iowa State (- 2.5)
• Pick OU: Over (154.5)
  
• Prediction: Iowa State 87 - BYU 79