Houston vs. Arizona Dunkel Predictions & Vegas Odds - Feb. 21

The No. 2 Houston Cougars (23-3, 11-2 Big 12) play the No. 4 Arizona Wildcats (24-2, 11-2 Big 12) on February 21, 2026 at Fertitta Center. The Cougars are favored, by 4.5 points, in a matchup featuring two of the best defensive teams in the country. The matchup's over/under is 141.5.

Houston is coming off of a 70-67 loss to Iowa State in its most recent outing on Monday. In Houston's loss, Kingston Flemings led the way with a team-high 22 points (adding five rebounds and four assists). Arizona's most recent game on Wednesday ended in a 75-68 victory against BYU. Anthony Dell'Orso recorded 22 points, four rebounds and zero assists for Arizona.

Houston vs. Arizona Odds and Game Time

• When: Saturday, February 21, 2026 at 3 p.m. ET
• Where: Fertitta Center in Houston, Texas
• Spread favorite: Houston -4.5
• Moneyline favorite: Houston -233
• Moneyline underdog: Arizona +186
• Over/Under: 141.5 points

How to watch Houston vs. Arizona

• TV Channel: ABC
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Houston vs. Arizona

• Houston and its opponents have combined to go over Saturday's over/under of 141.5 points 11 times this season.
• This season, 19 of Arizona's games have ended with a combined score higher than 141.5 points.
• Together, the two teams combine for 165.5 points per game, 24.0 points more than the total of 141.5 for this contest.
• These two teams give up a combined 130.2 points per game, 11.3 less than this contest's over/under.
• This season the average over/under for Houston's games is 139.5 points, 2.0 fewer than the over/under of 141.5 set for this contest.
• Arizona's games have an average over/under of 156.3 points this season, 14.8 more points than the over/under for this matchup.

Betting the Spread: Houston vs. Arizona

• In Houston's 26 games this season, it has 14 wins against the spread.
• The Cougars have an ATS record of 12-9 in their 21 games when favored by 4.5 points or more so far this season.
• Against the spread, Arizona is 15-11-0 this season.
• The Wildcats have been underdogs by 4.5 points or more once this season and covered the spread.
• Houston is 8-5 against the spread, and 13-0 overall, at home this year.
• At home, as a 4.5-point favorite or more, Houston is 8-5 ATS.
• Arizona is 6-1 overall, and 4-3 against the spread, in away games.
• Arizona has two wins ATS (2-2) as 4.5-point underdogs or more on the road.

Betting the Moneyline: Houston vs. Arizona

• This season, Houston has won 19 out of the 21 games, or 90.5%, in which it has been the moneyline favorite.
• The Cougars have entered 18 games this season favored by -233 or more, and won each of those games.
• Bookmakers have implied with the moneyline set for this matchup that Houston has a 70% chance to win.
• Arizona has won in each of the two contests it has played as moneyline underdogs this season.
• This is the worst odds of a win that sportsbooks have given the Wildcats this season with a +186 moneyline set for this game.
• Arizona has an implied victory probability of 35% according to the moneyline set by oddsmakers for this matchup.