NFL Predictions & Betting Odds - Week 2
15 September 2026
The Minnesota Vikings and the Chicago Bears take the field for one of many compelling matchups on the NFL schedule in Week 2.
We've got you covered with a quick rundown on every NFL tilt this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Continue reading for the details.
Bet now on FanDuel Sportsbook!Week 2 Games, Betting Info, and Predictions
There are 16 games on the NFL docket this week. Here's a look at each matchup:
Detroit Lions (1-1) at Buffalo Bills (2-0)
- Game Time: 8:15 p.m. ET | Thursday, September 17, 2026
- Venue: New Highmark Stadium (Orchard Park, New York)
- Total: 55.5
- Spread: Bills (-5.5)
- Moneyline: Bills (-238), Lions (+195)
Dunkel Index predictions:
- Over/Under: Over (55.5)
- ATS: Bills (-5.5)
- Score Prediction: Bills 37, Lions 27
Pittsburgh Steelers (1-1) at New England Patriots (1-1)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: Gillette Stadium (Foxborough, Massachusetts)
- Total: 41.5
- Spread: Patriots (-5.5)
- Moneyline: Patriots (-225), Steelers (+185)
Dunkel Index predictions:
- Over/Under: Under (41.5)
- ATS: Steelers (+5.5)
- Score Prediction: Patriots 16, Steelers 12
Carolina Panthers (1-1) at Atlanta Falcons (0-2)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: Mercedes-Benz Stadium (Atlanta, Georgia)
- Total: 43.5
- Spread: Panthers (-2.5)
- Moneyline: Panthers (-155), Falcons (+130)
Dunkel Index predictions:
- Over/Under: Over (43.5)
- ATS: Falcons (+2.5)
- Score Prediction: Falcons 33, Panthers 32
Green Bay Packers (1-1) at New York Jets (1-1)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: MetLife Stadium (East Rutherford, New Jersey)
- Total: 44.5
- Spread: Packers (-3.5)
- Moneyline: Packers (-185), Jets (+154)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Jets (+3.5)
- Score Prediction: Jets 29, Packers 18
Cincinnati Bengals (2-0) at Houston Texans (0-2)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: NRG Stadium (Houston, Texas)
- Total: 45.5
- Spread: Texans (-2.5)
- Moneyline: Texans (-148), Bengals (+124)
Dunkel Index predictions:
- Over/Under: Over (45.5)
- ATS: Texans (-2.5)
- Score Prediction: Texans 35, Bengals 28
Cleveland Browns (1-1) at Tampa Bay Buccaneers (0-2)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: Raymond James Stadium (Tampa, Florida)
- Total: 41.5
- Spread: Buccaneers (-7.5)
- Moneyline: Buccaneers (-426), Browns (+330)
Dunkel Index predictions:
- Over/Under: Over (41.5)
- ATS: Buccaneers (-7.5)
- Score Prediction: Buccaneers 33, Browns 19
Minnesota Vikings (2-0) at Chicago Bears (1-1)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: Soldier Field (Chicago, Illinois)
- Total: 46.5
- Spread: Bears (-4.5)
- Moneyline: Bears (-218), Vikings (+180)
Dunkel Index predictions:
- Over/Under: Over (46.5)
- ATS: Bears (-4.5)
- Score Prediction: Bears 47, Vikings 31
Philadelphia Eagles (2-0) at Tennessee Titans (0-2)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: Nissan Stadium (Nashville, Tennessee)
- Total: 39.5
- Spread: Eagles (-7.5)
- Moneyline: Eagles (-325), Titans (+260)
Dunkel Index predictions:
- Over/Under: Over (39.5)
- ATS: Titans (+7.5)
- Score Prediction: Eagles 22, Titans 18
New Orleans Saints (1-1) at Baltimore Ravens (1-1)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: M&T Bank Stadium (Baltimore, Maryland)
- Total: 45.5
- Spread: Ravens (-7.5)
- Moneyline: Ravens (-375), Saints (+295)
Dunkel Index predictions:
- Over/Under: Over (45.5)
- ATS: Ravens (-7.5)
- Score Prediction: Ravens 39, Saints 24
Jacksonville Jaguars (1-1) at Denver Broncos (1-1)
- Game Time: 4:05 p.m. ET | Sunday, September 20, 2026
- Venue: Empower Field at Mile High (Denver, Colorado)
- Total: 45.5
- Spread: Broncos (-2.5)
- Moneyline: Broncos (-148), Jaguars (+124)
Dunkel Index predictions:
- Over/Under: Under (45.5)
- ATS: Jaguars (+2.5)
- Score Prediction: Jaguars 26, Broncos 17
Las Vegas Raiders (2-0) at Los Angeles Chargers (0-2)
- Game Time: 4:05 p.m. ET | Sunday, September 20, 2026
- Venue: SoFi Stadium (Inglewood, California)
- Total: 43.5
- Spread: Chargers (-6.5)
- Moneyline: Chargers (-325), Raiders (+260)
Dunkel Index predictions:
- Over/Under: Under (43.5)
- ATS: Chargers (-6.5)
- Score Prediction: Chargers 25, Raiders 15
Washington Commanders (0-2) at Dallas Cowboys (1-1)
- Game Time: 4:25 p.m. ET | Sunday, September 20, 2026
- Venue: AT&T Stadium (Arlington, Texas)
- Total: 51.5
- Spread: Cowboys (-4.5)
- Moneyline: Cowboys (-205), Commanders (+170)
Dunkel Index predictions:
- Over/Under: Under (51.5)
- ATS: Commanders (+4.5)
- Score Prediction: Cowboys 25, Commanders 22
Miami Dolphins (0-2) at San Francisco 49ers (2-0)
- Game Time: 4:25 p.m. ET | Sunday, September 20, 2026
- Venue: Levi's Stadium (Santa Clara, California)
- Total: 45.5
- Spread: 49ers (-13.5)
- Moneyline: 49ers (-901), Dolphins (+600)
Dunkel Index predictions:
- Over/Under: Under (45.5)
- ATS: 49ers (-13.5)
- Score Prediction: 49ers 32, Dolphins 5
Seattle Seahawks (2-0) at Arizona Cardinals (1-1)
- Game Time: 4:25 p.m. ET | Sunday, September 20, 2026
- Venue: State Farm Stadium (Glendale, Arizona)
- Total: 41.5
- Spread: Seahawks (-4.5)
- Moneyline: Seahawks (-218), Cardinals (+180)
Dunkel Index predictions:
- Over/Under: Under (41.5)
- ATS: Cardinals (+4.5)
- Score Prediction: Cardinals 17, Seahawks 14
Indianapolis Colts (0-2) at Kansas City Chiefs (2-0)
- Game Time: 8:20 p.m. ET | Sunday, September 20, 2026
- Venue: GEHA Field at Arrowhead Stadium (Kansas City, Missouri)
- Total: 46.5
- Spread: Chiefs (-5.5)
- Moneyline: Chiefs (-265), Colts (+215)
Dunkel Index predictions:
- Over/Under: Over (46.5)
- ATS: Chiefs (-5.5)
- Score Prediction: Chiefs 48, Colts 4
New York Giants (1-0) at Los Angeles Rams (0-1)
- Game Time: 8:15 p.m. ET | Monday, September 21, 2026
- Venue: SoFi Stadium (Inglewood, California)
- Total: 47.5
- Spread: Rams (-6.5)
- Moneyline: Rams (-298), Giants (+240)
Dunkel Index predictions:
- Over/Under: Under (47.5)
- ATS: Giants (+6.5)
- Score Prediction: Giants 30, Rams 11
