NFL Predictions & Betting Odds - Week 2
15 September 2026
There are plenty of exciting matchups on the Week 2 NFL schedule, including the Seattle Seahawks squaring off against the Arizona Cardinals.
We've got you covered with a fast summary on every NFL tilt this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Keep scrolling for the key information.
Bet now on FanDuel Sportsbook!Week 2 Games, Betting Info, and Predictions
There are 16 games on the NFL docket this week. Here's a peek at each one:
Detroit Lions (1-0) at Buffalo Bills (1-0)
- Game Time: 8:15 p.m. ET | Thursday, September 17, 2026
- Venue: New Highmark Stadium (Orchard Park, New York)
- Total: 54.5
- Spread: Bills (-4.5)
- Moneyline: Bills (-218), Lions (+180)
Dunkel Index predictions:
- Over/Under: Over (54.5)
- ATS: Bills (-4.5)
- Score Prediction: Bills 37, Lions 27
Pittsburgh Steelers (1-0) at New England Patriots (0-1)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: Gillette Stadium (Foxborough, Massachusetts)
- Total: 41.5
- Spread: Patriots (-5.5)
- Moneyline: Patriots (-218), Steelers (+180)
Dunkel Index predictions:
- Over/Under: Under (41.5)
- ATS: Patriots (-5.5)
- Score Prediction: Patriots 18, Steelers 10
Carolina Panthers (0-1) at Atlanta Falcons (0-1)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: Mercedes-Benz Stadium (Atlanta, Georgia)
- Total: 43.5
- Spread: Panthers (-2.5)
- Moneyline: Panthers (-135), Falcons (+114)
Dunkel Index predictions:
- Over/Under: Over (43.5)
- ATS: Falcons (+2.5)
- Score Prediction: Falcons 33, Panthers 31
Green Bay Packers (0-1) at New York Jets (1-0)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: MetLife Stadium (East Rutherford, New Jersey)
- Total: 44.5
- Spread: Packers (-3.5)
- Moneyline: Packers (-205), Jets (+170)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Jets (+3.5)
- Score Prediction: Packers 24, Jets 23
Cincinnati Bengals (1-0) at Houston Texans (0-1)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: NRG Stadium (Houston, Texas)
- Total: 46.5
- Spread: Texans (-2.5)
- Moneyline: Texans (-142), Bengals (+120)
Dunkel Index predictions:
- Over/Under: Over (46.5)
- ATS: Texans (-2.5)
- Score Prediction: Texans 39, Bengals 24
Cleveland Browns (0-1) at Tampa Bay Buccaneers (0-1)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: Raymond James Stadium (Tampa, Florida)
- Total: 41.5
- Spread: Buccaneers (-8.5)
- Moneyline: Buccaneers (-395), Browns (+310)
Dunkel Index predictions:
- Over/Under: Over (41.5)
- ATS: Buccaneers (-8.5)
- Score Prediction: Buccaneers 32, Browns 20
Minnesota Vikings (1-0) at Chicago Bears (1-0)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: Soldier Field (Chicago, Illinois)
- Total: 48.5
- Spread: Bears (-5.5)
- Moneyline: Bears (-225), Vikings (+185)
Dunkel Index predictions:
- Over/Under: Over (48.5)
- ATS: Bears (-5.5)
- Score Prediction: Bears 44, Vikings 34
Philadelphia Eagles (1-0) at Tennessee Titans (0-1)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: Nissan Stadium (Nashville, Tennessee)
- Total: 39.5
- Spread: Eagles (-7)
- Moneyline: Eagles (-310), Titans (+250)
Dunkel Index predictions:
- Over/Under: Over (39.5)
- ATS: Titans (+7)
- Score Prediction: Eagles 23, Titans 16
New Orleans Saints (0-1) at Baltimore Ravens (1-0)
- Game Time: 1 p.m. ET | Sunday, September 20, 2026
- Venue: M&T Bank Stadium (Baltimore, Maryland)
- Total: 47.5
- Spread: Ravens (-7.5)
- Moneyline: Ravens (-410), Saints (+320)
Dunkel Index predictions:
- Over/Under: Over (47.5)
- ATS: Ravens (-7.5)
- Score Prediction: Ravens 36, Saints 26
Jacksonville Jaguars (1-0) at Denver Broncos (0-1)
- Game Time: 4:05 p.m. ET | Sunday, September 20, 2026
- Venue: Empower Field at Mile High (Denver, Colorado)
- Total: 45.5
- Spread: Broncos (-2.5)
- Moneyline: Broncos (-155), Jaguars (+130)
Dunkel Index predictions:
- Over/Under: Under (45.5)
- ATS: Jaguars (+2.5)
- Score Prediction: Jaguars 24, Broncos 18
Las Vegas Raiders (1-0) at Los Angeles Chargers (0-1)
- Game Time: 4:05 p.m. ET | Sunday, September 20, 2026
- Venue: SoFi Stadium (Inglewood, California)
- Total: 43.5
- Spread: Chargers (-6.5)
- Moneyline: Chargers (-298), Raiders (+240)
Dunkel Index predictions:
- Over/Under: Under (43.5)
- ATS: Chargers (-6.5)
- Score Prediction: Chargers 27, Raiders 13
Washington Commanders (0-1) at Dallas Cowboys (0-1)
- Game Time: 4:25 p.m. ET | Sunday, September 20, 2026
- Venue: AT&T Stadium (Arlington, Texas)
- Total: 50.5
- Spread: Cowboys (-3.5)
- Moneyline: Cowboys (-218), Commanders (+180)
Dunkel Index predictions:
- Over/Under: Under (50.5)
- ATS: Cowboys (-3.5)
- Score Prediction: Cowboys 26, Commanders 21
Miami Dolphins (0-1) at San Francisco 49ers (1-0)
- Game Time: 4:25 p.m. ET | Sunday, September 20, 2026
- Venue: Levi's Stadium (Santa Clara, California)
- Total: 45.5
- Spread: 49ers (-12.5)
- Moneyline: 49ers (-952), Dolphins (+625)
Dunkel Index predictions:
- Over/Under: Under (45.5)
- ATS: 49ers (-12.5)
- Score Prediction: 49ers 30, Dolphins 7
Seattle Seahawks (1-0) at Arizona Cardinals (1-0)
- Game Time: 4:25 p.m. ET | Sunday, September 20, 2026
- Venue: State Farm Stadium (Glendale, Arizona)
- Total: 40.5
- Spread: Seahawks (-4.5)
- Moneyline: Seahawks (-218), Cardinals (+180)
Dunkel Index predictions:
- Over/Under: Under (40.5)
- ATS: Seahawks (-4.5)
- Score Prediction: Seahawks 22, Cardinals 10
Indianapolis Colts (0-1) at Kansas City Chiefs (1-0)
- Game Time: 8:20 p.m. ET | Sunday, September 20, 2026
- Venue: GEHA Field at Arrowhead Stadium (Kansas City, Missouri)
- Total: 46.5
- Spread: Chiefs (-6.5)
- Moneyline: Chiefs (-285), Colts (+230)
Dunkel Index predictions:
- Over/Under: Over (46.5)
- ATS: Colts (+6.5)
- Score Prediction: Colts 27, Chiefs 26
New York Giants (1-0) at Los Angeles Rams (0-1)
- Game Time: 8:15 p.m. ET | Monday, September 21, 2026
- Venue: SoFi Stadium (Inglewood, California)
- Total: 48.5
- Spread: Rams (-7)
- Moneyline: Rams (-355), Giants (+280)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: Rams (-7)
- Score Prediction: Rams 29, Giants 12
