Seahawks vs. 49ers Week 5 Dunkel NFL Picks, Predictions and Odds

The Seattle Seahawks (3-1) are small favorites (-2.5) over the San Francisco 49ers (4-0), despite the 49ers having won four games in a row. The expected point total for the matchup is set at 46.5.

The Seahawks rank 13th in total offense this season (347.3 yards per game), but they've been shining on defense, ranking best in the NFL with 347.3 yards allowed per game. With 389.0 total yards per game on offense, the 49ers rank seventh in the NFL in 2026. On defense, they rank seventh, surrendering 308.8 total yards per contest.

Seahawks vs. 49ers Odds and Game Time

• Date: Sunday, October 11, 2026
• Time: 4:25 p.m. ET
• City: Seattle, Washington
• Venue: Lumen Field
• Total: 46.5 points
• Spread: Seahawks -2.5
• Moneyline: Seahawks (-155), 49ers (+130)

How to watch Seahawks vs. 49ers

• TV Channel: FOX

Betting the Over/Under: Seahawks vs. 49ers

• Seahawks games have gone over 46.5 points twice this season (in four outings).
• This season, games featuring the Seahawks have gone over the point total twice.
• The 49ers and their opponents have combined to score more than 46.5 points twice this season.
• So far this season, two San Francisco games have gone over the point total.
• The two teams combine to score 56.8 points per game, 10.3 more points than this matchup's over/under.
• These two teams surrender a combined 34.3 points per game, 12.2 fewer points than this contest's over/under.

Betting the Spread: Seahawks vs. 49ers

• Seattle has covered the spread once in four games this season.
• Seattle has been favored by 2.5 points or more four times this season, and covered the spread in one of those matchups.
• The 49ers are 3-1-0 ATS this season.
• San Francisco has covered the spread when playing as at least 2.5-point underdogs in its only opportunity this season.

Betting the Moneyline: Seahawks vs. 49ers

• Seattle has been the moneyline favorite four total times this season. They've finished 3-1 in those games.
• The 49ers won the only game they've played as the underdog this season.
• Seattle has a record of 3-1 when it has played as a moneyline favorite with odds of -155 or shorter (75%).
• San Francisco has played as an underdog of +130 or more once this season and won that game.
• The Seahawks have a 60.8% chance to win this contest based on the moneyline's implied probability.

Dunkel Prediction for Seahawks vs. 49ers

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