Boston University vs. Holy Cross Dunkel Predictions & Vegas Odds - Feb. 25

The Boston University Terriers (13-16, 8-8 Patriot League) play the Holy Cross Crusaders (10-19, 5-11 Patriot League) on February 25, 2026 at Case Gym. The Crusaders are underdogs by an 8.5-point margin as they enter the matchup with a 6-4 record in their last 10 games. The over/under is set at 142 for the matchup.

Boston University enters this contest following a 70-67 loss to Lehigh on Sunday. In Boston University's loss, Chance Gladden led the way with a team-high 17 points (adding five rebounds and four assists). Holy Cross' last outing on Sunday ended in a 72-63 win over Bucknell. Gabe Warren recorded 21 points, seven rebounds and three assists for Holy Cross.

Boston University vs. Holy Cross Odds and Game Time

• When: Wednesday, February 25, 2026 at 7 p.m. ET
• Where: Case Gym in Boston, Massachusetts
• Spread favorite: Boston University -8.5
• Moneyline favorite: Boston University -444
• Moneyline underdog: Holy Cross +326
• Over/Under: 142 points

How to watch Boston University vs. Holy Cross

• TV Channel: ESPN+
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Boston University vs. Holy Cross

• Boston University and its opponents have combined to outscore Wednesday's total (142 points) 18 times this season.
• In Holy Cross' 27 games this season, 15 finished with more combined points than Wednesday's total of 142.
• Together, the two teams combine for 144.5 points per game, 2.5 points more than the total of 142 for this matchup.
• The 147.7 points per game these two teams surrender to opponents on average this season are 5.7 more than the 142 over/under in this contest.
• Boston University has a 151.0 average over/under in its games this season, 9.0 more points than the over/under in this matchup.
• The over/under for this contest is 0.8 points higher than the average over/under in Holy Cross' games this season of 141.2.

Betting the Spread: Boston University vs. Holy Cross

• Against the spread, Boston University is 13-15-0 this season.
• The Terriers have been favored by 8.5 points or more one time this season and have not covered the spread in any of them.
• Holy Cross is 14-13-0 against the spread this year.
• So far this year, the Crusaders have been installed as underdogs by an 8.5-point margin or more nine times and are 6-3 ATS in those matchups.
• Boston University is 6-6 against the spread, and 7-5 overall, at home this season.
• At home, Boston University is winless ATS (0-1) as a 8.5-point favorite or more.
• In away games, Holy Cross is 7-8 against the spread, and 3-12 overall.

Betting the Moneyline: Boston University vs. Holy Cross

• Boston University has been the moneyline favorite in 16 games this season and won nine (56.2%) of those contests.
• The Terriers have played as a favorite of -444 or more once this season and lost that game.
• Boston University has a 81.6% chance to win this game based on the implied probability of the moneyline.
• Holy Cross has come away with seven wins in the 25 contests it has been listed as the moneyline underdog this season.
• This year, the Crusaders have won two of nine games when listed as at least +326 or worse on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that Holy Cross has a 23.5% chance of pulling out a win.

Dunkel Index Prediction for Boston University vs. Holy Cross

• Pick ATS: Holy Cross (+ 8.5)
• Pick OU: Over (142)
  
• Prediction: Holy Cross 74 - Boston University 73