American vs. Lafayette Dunkel Predictions & Vegas Odds - Feb. 22

The American Eagles (15-13, 8-7 Patriot League) visit the Lafayette Leopards (9-19, 6-9 Patriot League) at Kirby Sports Center, tipping off at 12 p.m. ET on Sunday, February 22, 2026. The Leopards are 4.5-point underdogs in the game. The matchup has an over/under of 140.5.

Their last time out, American won on Wednesday 75-57 against Bucknell. Madden Collins totaled 16 points, four rebounds and two assists for American. Lafayette's most recent outing on Wednesday ended in an 86-83 victory over Holy Cross. In Lafayette's win, Ryan Pettit led the team with 19 points (adding seven rebounds and one assist).

American vs. Lafayette Odds and Game Time

• When: Sunday, February 22, 2026 at 12 p.m. ET
• Where: Kirby Sports Center in Easton, Pennsylvania
• Spread favorite: American -4.5
• Moneyline favorite: American -198
• Moneyline underdog: Lafayette +159
• Over/Under: 140.5 points

How to watch American vs. Lafayette

• TV Channel: ESPN+
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: American vs. Lafayette

• American and its opponents have hit the over on this game's total (140.5 points) 15 times this season.
• A total of 17 of Lafayette's games have finished with a combined score higher than 140.5 points this season.
• The over/under for the game of 140.5 is 3.5 points fewer than the combined points per game averages for the Eagles (75.0 points per game) and the Leopards (69.0 points per game).
• This matchup's over/under is 5.2 fewer points than the 145.7 these two teams combine to allow per game in 2024.
• American has a 146.5 average over/under in its games this season, 6.0 more points than the over/under in this matchup.
• A difference of 2.7 points separates the average over/under in Lafayette's games (143.2 points) and this contest's over/under (140.5).

Betting the Spread: American vs. Lafayette

• Against the spread, American is 15-11-0 this year.
• The Eagles have been favored by 4.5 points or more 12 times this season and are 7-5 ATS in those contests.
• Lafayette has 12 wins against the spread in 27 games this year.
• So far this year, the Leopards have been installed as underdogs by a 4.5-point margin or more 12 times and are 6-6 ATS in those games.
• At home this year, Lafayette is 3-9 against the spread and 4-8 overall.
• At home, as a 4.5-point underdog or greater, Lafayette is winless ATS (0-2).
• Away from home, American is 4-9 overall and 7-6 against the spread.
• American has two wins ATS (2-1) away from home as 4.5-point favorites or more.

Betting the Moneyline: American vs. Lafayette

• American has entered the game as moneyline favorites 15 times this season and won 10, or 66.7%, of those games.
• The Eagles have a record of 7-3 in games where oddsmakers favor them by at least -198 on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that American has a 66.4% chance to win.
• Lafayette has come away with three wins in the 18 contests it has been listed as the moneyline underdog this season.
• This season, the Leopards have been victorious one time in 12 chances when named as an underdog of at least +159 or longer on the moneyline.
• Lafayette has an implied victory probability of 38.6% according to the moneyline set by sportsbooks for this matchup.