SMU vs. Syracuse Dunkel NCAA Football Picks, Predictions and Odds - Oct. 4

The Syracuse Orange (3-2) are 17.5-point underdogs in a road ACC matchup with the SMU Mustangs (2-2) on Saturday, October 4, 2025 at Gerald J. Ford Stadium.

In their most recent action, the Mustangs lost against the TCU Horned Frogs, 35-24.

In their most recent contest, the Orange lost against the Duke Blue Devils, 38-3.

SMU vs. Syracuse Predictions

Ahead of the upcoming game between the SMU Mustangs and Syracuse Orange, computer-calculated against-the-spread, over/under, and score predictions are below, sourced from Dunkel Index.

• Pick ATS: Mustangs (- 17.5)
• Pick OU: Over (58.5)
  
• Prediction: Mustangs 43 - Orange 23

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SMU vs. Syracuse Moneylines

Grab a peek below at the most up-to-date moneylines for the Mustangs-Orange game.

• SMU Moneyline: -820
• Syracuse Moneyline: +562

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SMU Betting Insights

• SMU has been the moneyline favorite only two other times so far this season, and they split the two games.
• SMU has played as a moneyline favorite of -820 or shorter in just one game this season, which it won.
• Mustangs games have had a combined total of more than 58.5 points two times this season (over four outings).
• The Mustangs have an average point total of 63.2 in their matchups this year, 4.7 more points than this game's over/under.
• The Mustangs are the 60th-highest scoring team in college football this year. The Orange have scored the 34th-most points.

Syracuse Betting Insights

• This season, Syracuse has won one out of the three games in which it has been the underdog.
• Syracuse has played as an underdog of +562 or more once this season and won that game.
• Syracuse has combined with its opponent to score more than 58.5 points only twice this season.
• Syracuse has had an average of 57.5 points scored in their games so far this season, 1.0 points fewer than this game's over/under.

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Key Stats for SMU vs. Syracuse

• Despite having a bottom-25 defense that ranks 13th-worst in the FBS (449.3 yards allowed per game), the Mustangs have put up better results offensively, ranking 52nd in the FBS by totaling 422.5 yards per game.
• SMU ranks 44th in scoring offense (34.8 points per game) and 88th in scoring defense (26.5 points allowed per game) this season.
• The Orange's defense has been bottom-25 in total defense this season, surrendering 464.6 total yards per game, which ranks 11th-worst. Offensively, they rank 39th with 441.0 total yards per contest.
• Syracuse has been struggling on defense, ranking 25th-worst with 29.6 points allowed per game. It has been more effective offensively, generating 31.2 points per contest (64th-ranked).