2025 CFL Week 21 Betting Preview

The Ottawa RedBlacks and Hamilton Tiger-Cats kick off Week 21 of the CFL regular season on Friday at Hamilton Stadium. The RedBlacks (4-13) are trying to bounce back from a 39-28 loss against Montreal last week, while the Tiger-Cats (10-7) are coming off a bye week following a 37-20 loss to Calgary in Week 19.

OTTAWA AT HAMILTON ODDS, GAME TIME

• Game Day: Friday, October 24, 2025
• Game Time: 7:00 PM ET
• Location: Hamilton, ON
• Stadium: Hanmilton Stadium
• Favorite: Hamilton Tiger-Cats
• Underdog: Ottawa RedBlacks
• Over/Under: 52.5
• Point Spread: Hamilton (-13.5)

HOW TO WATCH OTTAWA AT HAMILTON

• TV Channel: CBSSN

DUNKEL INDEX PREDICTION FOR OTTAWA AT HAMILTON

Dunkel Ratings: Ottawa 104.240; Hamilton 106.106
Dunkel Line & Total: Hamilton by 2; 46
Vegas Line & Total: Hamilton by 13 1/2; 52 1/2
Dunkel Pick: Ottawa (+13 1/2); Under

Below are all of Dunkel's Picks for Week 21 of the CFL schedule:

DUNKEL INDEX PREDICTION FOR CALGARY AT EDMONTON

Date: October 24, 2025
Time: 10:30 pm ET
Dunkel Ratings: Calgary 116.165; Edmonton 115.029
Dunkel Line & Total: Calgary by 1; 57
Vegas Line & Total: Calgary by 5; 53 1/2
Dunkel Pick: Edmonton (+5); Over

DUNKEL INDEX PREDICTION FOR MONTREAL AT WINNIPEG

Date: October 25, 2025
Time: 3:00 pm ET
Dunkel Ratings: Montreal 111.345; Winnipeg 121.975
Dunkel Line & Total: Winnipeg by 10 1/2; 46
Vegas Line & Total: Winnipeg by 5 1/2; 49 1/2
Dunkel Pick: Winnipeg (-5 1/2); Under

DUNKEL INDEX PREDICTION FOR BC AT SASKATCHEWAN

Date: October 25, 2025
Time: 7:00 pm ET
Dunkel Ratings: BC 127.538; Saskatchewan 106.990
Dunkel Line & Total: BC by 20 1/2; 48
Vegas Line & Total: BC by 7 1/2; 51 1/2
Dunkel Pick: BC (-7 1/2); Under