Dodgers vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - April 21

The Los Angeles Dodgers visit the San Francisco Giants to open a three-game series at Oracle Park, with first pitch at 9:45 p.m. ET on Tuesday. Yoshinobu Yamamoto (2-1, 2.10 ERA) gets the start for the Dodgers, who are 16-6 this season and first in the NL West. Landen Roupp (3-1, 2.38 ERA) is starting for the Giants, who are 9-13 and fourth in the NL West.

Despite playing on the road, the Dodgers are still a decent moneyline favorite (-185) over the Giants (+153). The over/under for the Dodgers-Giants game is set at 7.

Dodgers vs. Giants Odds, Game Time

• Game day: Tuesday, April 21, 2026
• Game time: 9:45 p.m. ET
• Location: San Francisco, California
• Stadium: Oracle Park
• Favorite: Dodgers (-185)
• Underdog: Giants (+153)
• Over/under: 7

How to Watch Dodgers vs. Giants

• TV Channel: NBCS-BA and SportsNet LA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Dodgers vs. Giants: Betting the Moneyline

• The Dodgers have put together a 16-6 record in games they were favored on the moneyline (winning 72.7% of those games).
• San Francisco has been underdogs in 14 games this season and has come away with the win six times (42.9%) in those contests.
• Los Angeles has entered 16 games this season favored by -185 or more and is 12-4 in those contests.
• Oddsmakers have given the Giants the worst odds of winning they have seen this season with a +153 moneyline listed for this contest.
• The implied moneyline probablility in this matchup gives the Dodgers a 64.9% chance to win.
• The moneyline set for this matchup implies the Giants have a 39.5% chance of coming away with a victory in the contest.

Dodgers vs. Giants: Betting the Spread & Total

• The Dodgers have had an over/under set by oddsmakers 22 times, and have combined with opponents to go over the total in 11 of those games (11-11-0).
• Games involving San Francisco have gone over the total set by sportsbooks in 10 of 22 chances this season.
• The Dodgers have a 12-10-0 record against the spread this season (covering 54.5% of the time).
• In 22 games with a line this season, the Giants have a mark of 7-15-0 against the spread.