Padres vs. Rockies Dunkel MLB Picks, Predictions and Prop Bets - April 21

The San Diego Padres and Colorado Rockies clash on Tuesday at 8:40 p.m. ET, opening a three-game series at Coors Field. Randy Vasquez (1-0, 2.49 ERA) gets the start for the Padres, who are 15-7 this season and second in the NL West. Jimmy Herget (0-1, 1.64 ERA) is the expected starter for the Rockies, who are 9-14 and fifth in the NL West.

Despite playing on the road, the Padres are still a decent moneyline favorite (-147) over the Rockies (+123). The game has an over/under set at 11 runs.

Padres vs. Rockies Odds, Game Time

• Game day: Tuesday, April 21, 2026
• Game time: 8:40 p.m. ET
• Location: Denver, Colorado
• Stadium: Coors Field
• Favorite: Padres (-147)
• Underdog: Rockies (+123)
• Over/under: 11

How to Watch Padres vs. Rockies

• TV Channel: COLR and SDPA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Padres vs. Rockies: Betting the Moneyline

• The Padres have been the moneyline favorite 10 total times this season. They've finished 8-2 in those games.
• Colorado has been underdogs in 23 games this season and has come away with the win nine times (39.1%) in those contests.
• San Diego is undefeated in six games this season when favored by -147 or more on the moneyline.
• The Rockies have a win-loss record of 8-14 when favored by +123 or worse by sportsbooks this year.
• Based on this game's moneyline, the Padres have an implied win probability of 59.5%.
• The moneyline set for this matchup implies the Rockies have a 44.8% chance of walking away with the win.

Padres vs. Rockies: Betting the Spread & Total

• The Padres have played in 22 games with over/under set, and have combined with opponents to go over the total nine times (9-11-2).
• Colorado and its opponents have gone over the total this season in nine of its 23 opportunities.
• The Padres have a 15-7-0 record ATS this season.
• The Rockies have posted a record of 14-9-0 against the spread this season.