Diamondbacks vs. White Sox Dunkel MLB Picks, Predictions and Prop Bets - April 21

The Arizona Diamondbacks and Chicago White Sox square off in the first of a three-game series on Tuesday at Chase Field, at 9:40 p.m. ET. Merrill Kelly (1-0, 3.38 ERA) gets the start for the Diamondbacks, who are 13-9 this season and third in the NL West. Sean Burke (0-2, 4.43 ERA) is expected to start for the White Sox, who are 8-14 and fourth in the AL Central.

Sportsbooks have made the Diamondbacks a decent moneyline favorite (-153) at home over the White Sox (+127). The game's over/under is set at 9.

Diamondbacks vs. White Sox Odds, Game Time

• Game day: Tuesday, April 21, 2026
• Game time: 9:40 p.m. ET
• Location: Phoenix, Arizona
• Stadium: Chase Field
• Favorite: Diamondbacks (-153)
• Underdog: White Sox (+127)
• Over/under: 9

How to Watch Diamondbacks vs. White Sox

• TV Channel: ARID and CHSN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Diamondbacks vs. White Sox: Betting the Moneyline

• The Diamondbacks have won all five of the games they have been the moneyline favorite this season.
• Chicago has been pegged as an underdog in 22 games this year and has walked away with the win eight times (36.4%) in those games.
• Arizona has not been bigger favorites this season than the -153 moneyline set for this game.
• This year, the White Sox have won six of 13 games when listed as at least +127 or worse on the moneyline.
• Based on this game's moneyline, the Diamondbacks have an implied win probability of 60.5%.
• The White Sox have an implied victory probability of 44.1% according to the moneyline set for this matchup.

Diamondbacks vs. White Sox: Betting the Spread & Total

• In the 22 games in which bookmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 13 times (13-8-1).
• Games involving Chicago have gone over the total set by bookmakers in 14 of 22 chances this season.
• The Diamondbacks have a 17-5-0 record against the spread this season (covering 77.3% of the time).
• The White Sox have an against the spread record of 10-12-0 in 22 games with a line this season.