Cubs vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - Sept. 27

Seiya Suzuki takes a two-game homer streak into the Chicago Cubs' game against the St. Louis Cardinals at 2:20 p.m. ET on Saturday, at Wrigley Field. Jameson Taillon (10-7, 3.78 ERA) will start for the Cubs, who are 90-70 this season and second in the NL Central. Michael McGreevy (8-3, 4.35 ERA) is expected to start for the Cardinals, who are 78-82 and fourth in the NL Central.

With the Cardinals (+150) visiting, the Cubs (-180) are a solid favorite on the moneyline. The contest has a total set at 9.5.

Cubs vs. Cardinals Odds, Game Time

• Game day: Saturday, September 27, 2025
• Game time: 2:20 p.m. ET
• Location: Chicago, Illinois
• Stadium: Wrigley Field
• Favorite: Cubs (-180)
• Underdog: Cardinals (+150)
• Over/under: 9.5

How to Watch Cubs vs. Cardinals

• TV Channel: FanDuel Sports Network Indiana
• Live Stream: Fubo (Watch for free)

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Cubs vs. Cardinals: Betting the Moneyline

• The Cubs have been the moneyline favorite 114 total times this season. They've finished 72-42 in those games.
• St. Louis has been underdogs in 91 games this season and has come away with the win 44 times (48.4%) in those contests.
• Chicago has a record of 21-9, a 70% win rate, when favored by -180 or more by bookmakers this season.
• The Cardinals have a win-loss record of 4-14 when favored by +150 or worse by oddsmakers this year.
• Based on this contest's moneyline, the Cubs have an implied win probability of 64.3%.
• The moneyline set for this matchup implies the Cardinals have a 40% chance of coming away with a victory in the contest.

Cubs vs. Cardinals: Betting the Spread & Total

• The Cubs have had an over/under set by bookmakers 160 times, and have combined with opponents to go over the total in 74 of those games (74-76-10).
• So far this season, St. Louis and its opponents have hit the over in 80 of its 159 games with a total.
• The Cubs have a 75-85-0 record ATS this season.
• The Cardinals are 81-78-0 against the spread in their 159 games with a line set by sportsbooks this season.