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Padres vs. White Sox Dunkel MLB Picks, Predictions and Prop Bets - Sept. 21

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21 September 2025 By Data Skrive

The San Diego Padres and Chicago White Sox play on Sunday at 2:10 p.m. ET at Rate Field, attempting to break a 1-1 series tie. Michael King (4-3, 3.84 ERA) will start for the Padres, who are 84-71 this season and second in the NL West. Sean Burke (4-10, 4.29 ERA) is starting for the White Sox, who are 58-97 and fifth in the AL Central.

Despite playing on the road, the Padres are still a decent moneyline favorite (-182) over the White Sox (+151). The game has an over/under of 8 runs.

Padres vs. White Sox Odds, Game Time

Game day: Sunday, September 21, 2025
Game time: 2:10 p.m. ET
Location: Chicago, Illinois
Stadium: Rate Field
Favorite: Padres (-182)
Underdog: White Sox (+151)
Over/under: 8

How to Watch Padres vs. White Sox

TV Channel: San Diego Padres (NEW)
Live Stream: Fubo (Watch for free)

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Padres vs. White Sox: Betting the Moneyline

The Padres have been the moneyline favorite 87 total times this season. They've gone 51-36 in those games.
Chicago has won in 57, or 37.5%, of the 152 contests it has been named as odds-on underdogs in this year.
San Diego has entered 28 games this season favored by -182 or more and is 18-10 in those contests.
The White Sox have a mark of 20-47 in contests where sportsbooks favor them by +151 or worse on the moneyline.
Based on this game's moneyline, the Padres' implied win probability is 64.5%.
The moneyline set for this matchup implies the White Sox have a 39.8% chance of coming away with a victory in the contest.

Padres vs. White Sox: Betting the Spread & Total

The Padres have played in 155 games with a set over/under, and have combined with their opponents to go over the total 66 times (66-83-6).
Chicago and its opponents have hit the over in 70 of its 155 games with a total this season.
The Padres have collected an 83-72-0 record against the spread this season (covering 53.5% of the time).
The White Sox have an against the spread mark of 90-65-0 in 155 games with a line this season.

Dunkel Index Prediction for Padres vs. White Sox

Pick OU: Under (8)
Prediction: Padres 5 - White Sox 2

Check out all the Dunkel Index MLB Baseball Picks!

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About the author

Data Skrive

Data Skrive creates sports articles about every player, on every team, in every league, for every game, for every fan. Data Skrive know sports. With over 100M monthly readers across 500+ websites and 200+ DMAs, their innovative Fan Engagement Solution creates engaging and entertaining sports content that fans value to drive revenue for their customers. Sports never stop, and covering every topic at the right time is not feasible. Data Skrive's technology is able to cover highly relevant topics that are interesting and engaging to your fans.