NFL Predictions & Betting Odds - Week 10
04 November 2025
The Week 10 NFL lineup has plenty of excitement, including a matchup between the Los Angeles Rams and the San Francisco 49ers.
We've got you sorted out with a fast summary on every NFL tilt this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Keep reading for the details.
Bet now on FanDuel Sportsbook!Week 10 Games, Betting Info, and Predictions
There are 14 games on the pro football slate this week. Below is a peek at each one:
Las Vegas Raiders (2-6) at Denver Broncos (7-2)
- Game Time: 8:15 p.m. ET | Thursday, November 6, 2025
- Venue: Empower Field at Mile High (Denver, Colorado)
- Total: 43.5
- Spread: Broncos (-8.5)
- Moneyline: Broncos (-500), Raiders (+380)
Dunkel Index predictions:
- Over/Under: Under (43.5)
- ATS: Broncos (-8.5)
- Score Prediction: Broncos 31, Raiders 12
Atlanta Falcons (3-5) at Indianapolis Colts (7-2)
- Game Time: 9:30 a.m. ET | Sunday, November 9, 2025
- Venue: Olympic Stadium Berlin (Berlin, Germany)
- Total: 48.5
- Spread: Colts (-6.5)
- Moneyline: Colts (-340), Falcons (+270)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: Colts (-6.5)
- Score Prediction: Colts 31, Falcons 15
Buffalo Bills (6-2) at Miami Dolphins (2-7)
- Game Time: 1 p.m. ET | Sunday, November 9, 2025
- Venue: Hard Rock Stadium (Miami Gardens, Florida)
- Total: 50.5
- Spread: Bills (-9.5)
- Moneyline: Bills (-455), Dolphins (+350)
Dunkel Index predictions:
- Over/Under: Under (50.5)
- ATS: Bills (-9.5)
- Score Prediction: Bills 30, Dolphins 19
New Orleans Saints (1-8) at Carolina Panthers (5-4)
- Game Time: 1 p.m. ET | Sunday, November 9, 2025
- Venue: Bank of America Stadium (Charlotte, North Carolina)
- Total: 40.5
- Spread: Panthers (-5.5)
- Moneyline: Panthers (-258), Saints (+210)
Dunkel Index predictions:
- Over/Under: Over (40.5)
- ATS: Panthers (-5.5)
- Score Prediction: Panthers 25, Saints 17
New York Giants (2-7) at Chicago Bears (5-3)
- Game Time: 1 p.m. ET | Sunday, November 9, 2025
- Venue: Soldier Field (Chicago, Illinois)
- Total: 47.5
- Spread: Bears (-4.5)
- Moneyline: Bears (-218), Giants (+180)
Dunkel Index predictions:
- Over/Under: Over (47.5)
- ATS: Giants (+4.5)
- Score Prediction: Bears 28, Giants 24
Cleveland Browns (2-6) at New York Jets (1-7)
- Game Time: 1 p.m. ET | Sunday, November 9, 2025
- Venue: MetLife Stadium (East Rutherford, New Jersey)
- Total: 38.5
- Spread: Browns (-2.5)
- Moneyline: Browns (-135), Jets (+114)
Dunkel Index predictions:
- Over/Under: Over (38.5)
- ATS: Jets (+2.5)
- Score Prediction: Jets 23, Browns 21
Baltimore Ravens (3-5) at Minnesota Vikings (4-4)
- Game Time: 1 p.m. ET | Sunday, November 9, 2025
- Venue: U.S. Bank Stadium (Minneapolis, Minnesota)
- Total: 49.5
- Spread: Ravens (-4.5)
- Moneyline: Ravens (-225), Vikings (+185)
Dunkel Index predictions:
- Over/Under: Under (49.5)
- ATS: Vikings (+4.5)
- Score Prediction: Vikings 25, Ravens 24
New England Patriots (7-2) at Tampa Bay Buccaneers (6-2)
- Game Time: 1 p.m. ET | Sunday, November 9, 2025
- Venue: Raymond James Stadium (Tampa, Florida)
- Total: 49.5
- Spread: Buccaneers (-2.5)
- Moneyline: Buccaneers (-142), Patriots (+120)
Dunkel Index predictions:
- Over/Under: Under (49.5)
- ATS: Buccaneers (-2.5)
- Score Prediction: Buccaneers 26, Patriots 20
Jacksonville Jaguars (5-3) at Houston Texans (3-5)
- Game Time: 1 p.m. ET | Sunday, November 9, 2025
- Venue: NRG Stadium (Houston, Texas)
- Total: 38.5
- Spread: Jaguars (-1.5)
- Moneyline: Jaguars (-112), Texans (-108)
Dunkel Index predictions:
- Over/Under: Over (38.5)
- ATS: Texans (+1.5)
- Score Prediction: Texans 24, Jaguars 16
Arizona Cardinals (3-5) at Seattle Seahawks (6-2)
- Game Time: 4:05 p.m. ET | Sunday, November 9, 2025
- Venue: Lumen Field (Seattle, Washington)
- Total: 45.5
- Spread: Seahawks (-6.5)
- Moneyline: Seahawks (-305), Cardinals (+245)
Dunkel Index predictions:
- Over/Under: Over (45.5)
- ATS: Seahawks (-6.5)
- Score Prediction: Seahawks 31, Cardinals 15
Los Angeles Rams (6-2) at San Francisco 49ers (6-3)
- Game Time: 4:25 p.m. ET | Sunday, November 9, 2025
- Venue: Levi's Stadium (Santa Clara, California)
- Total: 49.5
- Spread: Rams (-3.5)
- Moneyline: Rams (-218), 49ers (+180)
Dunkel Index predictions:
- Over/Under: Under (49.5)
- ATS: Rams (-3.5)
- Score Prediction: Rams 23, 49ers 19
Detroit Lions (5-3) at Washington Commanders (3-6)
- Game Time: 4:25 p.m. ET | Sunday, November 9, 2025
- Venue: Northwest Stadium (Landover, Maryland)
- Total: 49.5
- Spread: Lions (-8.5)
- Moneyline: Lions (-469), Commanders (+360)
Dunkel Index predictions:
- Over/Under: Over (49.5)
- ATS: Lions (-8.5)
- Score Prediction: Lions 30, Commanders 21
Pittsburgh Steelers (5-3) at Los Angeles Chargers (6-3)
- Game Time: 8:20 p.m. ET | Sunday, November 9, 2025
- Venue: SoFi Stadium (Inglewood, California)
- Total: 45.5
- Spread: Chargers (-3)
- Moneyline: Chargers (-166), Steelers (+140)
Dunkel Index predictions:
- Over/Under: Over (45.5)
- ATS: Chargers (-3)
- Score Prediction: Chargers 26, Steelers 22
Philadelphia Eagles (6-2) at Green Bay Packers (5-2-1)
- Game Time: 8:15 p.m. ET | Monday, November 10, 2025
- Venue: Lambeau Field (Green Bay, Wisconsin)
- Total: 45.5
- Spread: Packers (-2.5)
- Moneyline: Packers (-130), Eagles (+110)
Dunkel Index predictions:
- Over/Under: Over (45.5)
- ATS: Eagles (+2.5)
- Score Prediction: Eagles 25, Packers 23
