NFL Predictions & Betting Odds - Week 6
07 October 2025
The San Francisco 49ers and the Tampa Bay Buccaneers square off for one of many compelling matchups on the NFL slate in Week 6.
We've got you sorted out with a fast rundown on every NFL tilt this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Keep scrolling for the key information.
Bet now on FanDuel Sportsbook!Week 6 Games, Betting Info, and Predictions
There are 15 games on the pro football schedule this week. Here's a glance at each matchup:
Philadelphia Eagles (4-1) at New York Giants (1-4)
- Game Time: 8:15 p.m. ET | Thursday, October 9, 2025
- Venue: MetLife Stadium (East Rutherford, New Jersey)
- Total: 40.5
- Spread: Eagles (-7.5)
- Moneyline: Eagles (-395), Giants (+310)
Dunkel Index predictions:
- Over/Under: Over (40.5)
- ATS: Eagles (-7.5)
- Score Prediction: Eagles 28, Giants 16
Denver Broncos (3-2) at New York Jets (0-5)
- Game Time: 9:30 a.m. ET | Sunday, October 12, 2025
- Venue: Tottenham Hotspur Stadium (London, England)
- Total: 44.5
- Spread: Broncos (-7.5)
- Moneyline: Broncos (-395), Jets (+310)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Broncos (-7.5)
- Score Prediction: Broncos 34, Jets 13
Los Angeles Chargers (3-2) at Miami Dolphins (1-4)
- Game Time: 1 p.m. ET | Sunday, October 12, 2025
- Venue: Hard Rock Stadium (Miami Gardens, Florida)
- Total: 44.5
- Spread: Chargers (-4.5)
- Moneyline: Chargers (-225), Dolphins (+185)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Chargers (-4.5)
- Score Prediction: Chargers 25, Dolphins 20
Arizona Cardinals (2-3) at Indianapolis Colts (4-1)
- Game Time: 1 p.m. ET | Sunday, October 12, 2025
- Venue: Lucas Oil Stadium (Indianapolis, Indiana)
- Total: 47.5
- Spread: Colts (-7)
- Moneyline: Colts (-345), Cardinals (+275)
Dunkel Index predictions:
- Over/Under: Under (47.5)
- ATS: Colts (-7)
- Score Prediction: Colts 32, Cardinals 13
Los Angeles Rams (3-2) at Baltimore Ravens (1-4)
- Game Time: 1 p.m. ET | Sunday, October 12, 2025
- Venue: M&T Bank Stadium (Baltimore, Maryland)
- Total: 44.5
- Spread: Rams (-7.5)
- Moneyline: Rams (-360), Ravens (+285)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Rams (-7.5)
- Score Prediction: Rams 35, Ravens 20
New England Patriots (3-2) at New Orleans Saints (1-4)
- Game Time: 1 p.m. ET | Sunday, October 12, 2025
- Venue: Caesars Superdome (New Orleans, Louisiana)
- Total: 46.5
- Spread: Patriots (-3.5)
- Moneyline: Patriots (-192), Saints (+160)
Dunkel Index predictions:
- Over/Under: Under (46.5)
- ATS: Patriots (-3.5)
- Score Prediction: Patriots 25, Saints 20
Seattle Seahawks (3-2) at Jacksonville Jaguars (4-1)
- Game Time: 1 p.m. ET | Sunday, October 12, 2025
- Venue: EverBank Stadium (Jacksonville, Florida)
- Total: 47.5
- Spread: Jaguars (-1.5)
- Moneyline: Jaguars (-112), Seahawks (-108)
Dunkel Index predictions:
- Over/Under: Over (47.5)
- ATS: Jaguars (-1.5)
- Score Prediction: Jaguars 25, Seahawks 22
Cleveland Browns (1-4) at Pittsburgh Steelers (3-1)
- Game Time: 1 p.m. ET | Sunday, October 12, 2025
- Venue: Acrisure Stadium (Pittsburgh, Pennsylvania)
- Total: 38.5
- Spread: Steelers (-4.5)
- Moneyline: Steelers (-250), Browns (+205)
Dunkel Index predictions:
- Over/Under: Over (38.5)
- ATS: Steelers (-4.5)
- Score Prediction: Steelers 30, Browns 14
Dallas Cowboys (2-2-1) at Carolina Panthers (2-3)
- Game Time: 1 p.m. ET | Sunday, October 12, 2025
- Venue: Bank of America Stadium (Charlotte, North Carolina)
- Total: 49.5
- Spread: Cowboys (-3.5)
- Moneyline: Cowboys (-175), Panthers (+145)
Dunkel Index predictions:
- Over/Under: Over (49.5)
- ATS: Panthers (+3.5)
- Score Prediction: Panthers 29, Cowboys 23
Tennessee Titans (1-4) at Las Vegas Raiders (1-4)
- Game Time: 4:05 p.m. ET | Sunday, October 12, 2025
- Venue: Allegiant Stadium (Paradise, Nevada)
- Total: 41.5
- Spread: Raiders (-4.5)
- Moneyline: Raiders (-218), Titans (+180)
Dunkel Index predictions:
- Over/Under: Over (41.5)
- ATS: Titans (+4.5)
- Score Prediction: Titans 22, Raiders 21
San Francisco 49ers (4-1) at Tampa Bay Buccaneers (4-1)
- Game Time: 4:25 p.m. ET | Sunday, October 12, 2025
- Venue: Raymond James Stadium (Tampa, Florida)
- Total: 47.5
- Spread: Buccaneers (-3)
- Moneyline: Buccaneers (-162), 49ers (+136)
Dunkel Index predictions:
- Over/Under: Under (47.5)
- ATS: 49ers (+3)
- Score Prediction: Buccaneers 25, 49ers 22
Cincinnati Bengals (2-3) at Green Bay Packers (2-1-1)
- Game Time: 4:25 p.m. ET | Sunday, October 12, 2025
- Venue: Lambeau Field (Green Bay, Wisconsin)
- Total: 44.5
- Spread: Packers (-14.5)
- Moneyline: Packers (-1053), Bengals (+675)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Bengals (+14.5)
- Score Prediction: Packers 31, Bengals 17
Detroit Lions (4-1) at Kansas City Chiefs (2-3)
- Game Time: 8:20 p.m. ET | Sunday, October 12, 2025
- Venue: GEHA Field at Arrowhead Stadium (Kansas City, Missouri)
- Total: 53.5
- Spread: Chiefs (-2.5)
- Moneyline: Chiefs (-135), Lions (+114)
Dunkel Index predictions:
- Over/Under: Under (53.5)
- ATS: Lions (+2.5)
- Score Prediction: Lions 27, Chiefs 25
Buffalo Bills (4-1) at Atlanta Falcons (2-2)
- Game Time: 7:15 p.m. ET | Monday, October 13, 2025
- Venue: Mercedes-Benz Stadium (Atlanta, Georgia)
- Total: 50.5
- Spread: Bills (-5.5)
- Moneyline: Bills (-225), Falcons (+185)
Dunkel Index predictions:
- Over/Under: Under (50.5)
- ATS: Falcons (+5.5)
- Score Prediction: Falcons 25, Bills 22
Chicago Bears (2-2) at Washington Commanders (3-2)
- Game Time: 8:15 p.m. ET | Monday, October 13, 2025
- Venue: Northwest Stadium (Landover, Maryland)
- Total: 49.5
- Spread: Commanders (-5.5)
- Moneyline: Commanders (-225), Bears (+185)
Dunkel Index predictions:
- Over/Under: Over (49.5)
- ATS: Commanders (-5.5)
- Score Prediction: Commanders 31, Bears 19
