Panthers vs. Saints Week 10 Dunkel NFL Picks, Predictions and Odds

The Carolina Panthers (5-4) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -5.5) over the New Orleans Saints (1-8). The Saints have dropped four games straight. An over/under of 40.5 points has been set for the matchup.

The Panthers rank 22nd in total offense (310.7 yards per game) and 13th in total defense (316.6 yards allowed per game) this year. The Saints' offense has been bottom-five this season, putting up 15.3 points per game, which ranks second-worst in the NFL. On defense, they rank 24th with 27.0 points ceded per contest.

Panthers vs. Saints Odds and Game Time

• Date: Sunday, November 9, 2025
• Time: 1 p.m. ET
• City: Charlotte, North Carolina
• Venue: Bank of America Stadium
• Total: 40.5 points
• Spread: Panthers -5.5
• Moneyline: Panthers (-245), Saints (+200)

How to watch Panthers vs. Saints

• TV Channel: FOX (WDBD-Jackson, MS)
• Live Stream: Fubo

Betting the Over/Under: Panthers vs. Saints

• The Panthers and their opponents have gone over 40.5 combined points five times this season.
• Carolina and its opponent have combined to hit the over five out of nine times this season.
• Saints games this season have had a combined scoring total higher than 40.5 points in five of nine outings.
• New Orleans and its opponent have combined to hit the over three out of nine times this year.
• The teams average 34.2 points per game combined, 6.3 fewer than this matchup's total.
• These teams surrender 49.8 points per game combined, 9.3 more points than this matchup's over/under.

Betting the Spread: Panthers vs. Saints

• Carolina has covered the spread six times in nine games this season.
• The Saints have won just two games against the spread this season.
• New Orleans has been an underdog by 5.5 points or more four times this season, and covered the spread in one of those games.
• At home this year, the Panthers are 3-1 against the spread and 3-1 overall.
• Away from home, the Saints have only one win against the spread and are 0-4 overall.
• New Orleans has one win ATS (1-2) on the road as 5.5-point underdogs or more.

Betting the Moneyline: Panthers vs. Saints

• Carolina has not played as the moneyline favorite yet this season.
• This season, the Saints have been listed as the underdog in eight games and failed to win any of those contests.
• Carolina has not yet played a game with moneyline odds of -245 or shorter.
• This season, New Orleans has been at least a +200 underdog on the moneyline four times, losing each of those contests.
• The Panthers have a 71.0% chance to win this game based on the moneyline's implied probability.

Dunkel Prediction for Panthers vs. Saints

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