Panthers vs. Saints Week 10 Dunkel NFL Picks, Predictions and Odds

The Carolina Panthers (5-4) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -5.5) over the New Orleans Saints (1-8). The Saints have dropped four games straight. An over/under of 40.5 points has been established for the matchup.

The Panthers rank 27th in scoring offense (18.9 points per game) and 16th in scoring defense (22.8 points allowed per game) this year. The Saints' offense has been bottom-five in total offense this season, generating 287.1 total yards per game, which ranks fourth-worst in the NFL. On the defensive side of the ball, they rank 18th with 333.3 total yards allowed per contest.

Panthers vs. Saints Odds and Game Time

• Date: Sunday, November 9, 2025
• Time: 1 p.m. ET
• City: Charlotte, North Carolina
• Venue: Bank of America Stadium
• Total: 40.5 points
• Spread: Panthers -5.5
• Moneyline: Panthers (-245), Saints (+200)

How to watch Panthers vs. Saints

• TV Channel: FOX (WDBD-Jackson, MS)
• Live Stream: Fubo

Betting the Over/Under: Panthers vs. Saints

• The Panthers' nine games this season have gone over this contest's total of 40.5 points five times.
• Carolina games have hit the over five out of nine times this season.
• The Saints have played five games this season that have gone over 40.5 combined points scored.
• In New Orleans' nine contests this year, the combined scoring has gone over the point total three times.
• The two teams combine to score 34.2 points per game, 6.3 fewer points than this matchup's total.
• Combined, these teams give up 49.8 points per game, 9.3 more points than this matchup's total.

Betting the Spread: Panthers vs. Saints

• Carolina is 6-3-0 ATS this season.
• The Saints have covered just twice in nine matchups with a spread this year.
• New Orleans has been an underdog by 5.5 points or more four times this year, and covered the spread in one of those contests.
• The Panthers are 3-1 overall, and 3-1 against the spread, at home.
• The Saints have one win against the spread, and are 0-4 overall away from home.
• New Orleans has one win ATS (1-2) on the road as 5.5-point underdogs or more.

Betting the Moneyline: Panthers vs. Saints

• This is the first game this season Carolina is listed as the moneyline favorite.
• The Saints have been the underdog in eight games this season, and they have failed to win any of those contests.
• Carolina has not yet played as a moneyline favorite of -245 or shorter.
• New Orleans has been at least a +200 moneyline underdog four times this season, but lost all of those games.
• Based on this contest's moneyline, the Panthers' implied win probability is 71.0%.

Dunkel Prediction for Panthers vs. Saints

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