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Padres vs. White Sox Dunkel MLB Picks, Predictions and Prop Bets - Sept. 19

MLB Previews

19 September 2025 By Data Skrive

The San Diego Padres and Chicago White Sox square off on Friday at 7:40 p.m. ET, opening a three-game series at Rate Field. Dylan Cease (8-11, 4.59 ERA) will start for the Padres, who are 83-70 this season and second in the NL West. Davis Martin (6-10, 4.01 ERA) is the expected starter for the White Sox, who are 57-96 and fifth in the AL Central.

Bookmakers have set the Padres as the moderate moneyline favorites (-189) on the road versus the White Sox (+157). The game's over/under is set at 8.

Padres vs. White Sox Odds, Game Time

Game day: Friday, September 19, 2025
Game time: 7:40 p.m. ET
Location: Chicago, Illinois
Stadium: Rate Field
Favorite: Padres (-189)
Underdog: White Sox (+157)
Over/under: 8

How to Watch Padres vs. White Sox

TV Channel: San Diego Padres (NEW)
Live Stream: Fubo (Watch for free)

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Padres vs. White Sox: Betting the Moneyline

The Padres have been favored on the moneyline 85 total times this season. They've finished 50-35 in those games.
Chicago has come away with 56 wins in the 150 contests it has been listed as the underdogs in this season.
San Diego has a record of 15-8 in games when bookmakers favor them by at least -189 on the moneyline.
This season, the White Sox have come away with a win 17 times in 60 chances when named as an underdog of at least +157 or longer on the moneyline.
The Padres have an implied moneyline win probability of 65.4% in this matchup.
Bookmakers have implied with the moneyline set for this matchup that the White Sox have a 38.9% chance of pulling out a win.

Padres vs. White Sox: Betting the Spread & Total

The Padres have played in 153 games with set over/under, and have combined with opponents to go over the total 65 times (65-82-6).
Chicago and its opponents have gone over the total this season in 69 of its 153 opportunities.
The Padres have an 82-71-0 record ATS this season.
In 153 games with a line this season, the White Sox have a mark of 89-64-0 against the spread.