Indiana vs. Penn State Dunkel NCAA Football Picks, Predictions and Odds - Nov. 8

The No. 2 Indiana Hoosiers (9-0), who have college football's 17th-ranked pass defense, meet the Penn State Nittany Lions (3-5) and their 14th-ranked passing defense on Saturday, November 8, 2025. The Hoosiers are massive, 14.5-point favorites.

In their most recent action, the Hoosiers won against the Maryland Terrapins, 55-10.

Last time around, the Nittany Lions fell to the Ohio State Buckeyes, with 38-14 being the final score.

Indiana vs. Penn State Predictions

For insights on the upcoming game between the Indiana Hoosiers and Penn State Nittany Lions, computer-derived against-the-spread, over/under, and score predictions are below, per Dunkel Index.

• Pick ATS: Nittany Lions (+ 14.5)
• Pick OU: Over (48.5)
  
• Prediction: Hoosiers 31 - Nittany Lions 25

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Indiana vs. Penn State Moneylines

Snag a peek below at the latest moneylines for the Hoosiers-Nittany Lions matchup.

• Indiana Moneyline: -699
• Penn State Moneyline: +500

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Indiana Betting Insights

• Indiana has won all seven of the games it has been favored on the moneyline this season.
• Indiana has played five times as a moneyline favorite with odds of -699 or shorter, and claimed a victory in each game.
• In seven of nine games this season, the Hoosiers and their opponents have combined to score more than 48.5 points.
• The average point total in Hoosiers outings this year is 52.2, 3.7 more than this matchup's over/under.
• The Hoosiers are the highest scoring team in college football this year. The Nittany Lions have scored the 62nd-most points.

Penn State Betting Insights

• Penn State has lost both games it has played as underdogs this season.
• Penn State has played as an underdog of +500 or more once this season and lost that game.
• Penn State and its opponents have combined to score more than 48.5 points in six of eight games this season.
• The average total for Penn State games this season has been 49.9, 1.4 more points than this matchup's over/under.

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Key Stats for Indiana vs. Penn State

• In their past three head-to-head meetings, Penn State has won against Indiana three times.
• The last three times the Nittany Lions have matched up against the Hoosiers, they have posted a 2-1 record against the spread. The scoring has gone over the point total on two occasions.
• The Hoosiers have been surging on both offense and defense, ranking third-best in total offense (504.9 yards per game) and seventh-best in total defense (248.3 yards allowed per game).
• Indiana has been finding success on both offense and defense, ranking best in scoring offense (46.4 points per game) and third-best in scoring defense (10.8 points allowed per game).
• The Nittany Lions are generating 335.6 total yards per game on offense this season (108th-ranked). Meanwhile, they are giving up 325.8 total yards per game (34th-ranked).
• With 31.5 points per game on the offensive side of the ball, Penn State ranks 49th in the FBS. Defensively, it ranks 41st, surrendering 21.8 points per game.