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Brewers vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - Sept. 21

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21 September 2025 By Data Skrive

The Milwaukee Brewers and St. Louis Cardinals play on Sunday at 2:15 p.m. ET at Busch Stadium, attempting to break a 1-1 series tie. Freddy Peralta (17-6, 2.65 ERA) gets the start for the Brewers, who are 95-60 this season and first in the NL Central. Matthew Liberatore (7-12, 4.30 ERA) is expected to start for the Cardinals, who are 75-80 and fourth in the NL Central.

The Brewers are currently a moderate moneyline favorite (-140) on the road at the Cardinals (+117). The total in this contest is 8.5.

Brewers vs. Cardinals Odds, Game Time

Game day: Sunday, September 21, 2025
Game time: 2:15 p.m. ET
Location: St. Louis, Missouri
Stadium: Busch Stadium
Favorite: Brewers (-140)
Underdog: Cardinals (+117)
Over/under: 8.5

How to Watch Brewers vs. Cardinals

TV Channel: FanDuel Sports Network Indiana
Live Stream: Fubo (Watch for free)

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Brewers vs. Cardinals: Betting the Moneyline

The Brewers have won 64.8% of the games this season when they were favored on the moneyline (59-32).
St. Louis has been pegged as an underdog in 87 games this year and has walked away with the win 41 times (47.1%) in those games.
Milwaukee has entered 47 games this season favored by -140 or more and is 36-11 in those contests.
The Cardinals have a win-loss record of 19-29 when favored by +117 or worse by bookmakers this year.
The Brewers have an implied moneyline win probability of 58.3% in this matchup.
The moneyline set for this matchup implies the Cardinals have a 46.1% chance of walking away with the win.

Brewers vs. Cardinals: Betting the Spread & Total

The Brewers have played in 155 games with a set over/under, and have combined with their opponents to go over the total 75 times (75-74-6).
So far this season, St. Louis and its opponents have hit the over in 77 of its 154 games with a total.
The Brewers have put together an 87-68-0 record against the spread this season (covering 56.1% of the time).
The Cardinals are 78-76-0 against the spread in their 154 games that had a posted line this season.

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About the author

Data Skrive

Data Skrive creates sports articles about every player, on every team, in every league, for every game, for every fan. Data Skrive know sports. With over 100M monthly readers across 500+ websites and 200+ DMAs, their innovative Fan Engagement Solution creates engaging and entertaining sports content that fans value to drive revenue for their customers. Sports never stop, and covering every topic at the right time is not feasible. Data Skrive's technology is able to cover highly relevant topics that are interesting and engaging to your fans.