Louisville vs. SMU Dunkel Predictions & Vegas Odds - Jan. 31

The No. 20 Louisville Cardinals (14-6, 4-4 ACC) host the SMU Mustangs (15-5, 4-3 ACC) at KFC Yum! Center, starting at 2 p.m. ET on Saturday, January 31, 2026. The Mustangs are 9.5-point underdogs in the game. The matchup has an over/under of 161.5 points.

Louisville enters this game after an 83-52 loss to Duke on Monday. Ryan Conwell put up 18 points, three rebounds and three assists for Louisville. SMU took care of business in its most recent outing 83-80 against Florida State on Saturday. Jaron Pierre Jr. scored 28 points in SMU's win, leading the team.

Louisville vs. SMU Odds and Game Time

• When: Saturday, January 31, 2026 at 2 p.m. ET
• Where: KFC Yum! Center in Louisville, Kentucky
• Spread favorite: Louisville -9.5
• Moneyline favorite: Louisville -442
• Moneyline underdog: SMU +337
• Over/Under: 161.5 points

How to watch Louisville vs. SMU

• TV Channel: ESPN
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Louisville vs. SMU

• This season, Louisville's games have hit the over on this matchup's 161.5-point total six times.
• In SMU's 20 games this season, 13 finished with more combined points than Saturday's over/under of 161.5.
• The total for the contest of 161.5 is 11.8 points fewer than the combined points per game averages for the Cardinals (86.0 points per game) and the Mustangs (87.3 points per game).
• The 147.3 points per game these two teams surrender to opponents combined this season are 14.2 less than the 161.5-point over/under in this contest.
• This season the average over/under for Louisville's games is 156.3 points, 5.2 fewer than the over/under of 161.5 set for this contest.
• SMU's games have an average over/under of 164.3 points this season, 2.8 more points than the over/under for this game.

Betting the Spread: Louisville vs. SMU

• Against the spread, Louisville is 11-9-0 this year.
• The Cardinals have an against the spread record of 6-3 in their nine games when favored by 9.5 points or more so far this season.
• In SMU's 20 games this season, it has nine wins against the spread.
• The Mustangs have been underdogs by 9.5 points or more two times this season and covered the spread once.
• At home this season, Louisville is 7-5 against the spread and 10-2 overall.
• Louisville is 6-3 ATS as a 9.5-point favorite or more at home.
• On the road, SMU is 2-3 overall and 3-1-1 against the spread.

Betting the Moneyline: Louisville vs. SMU

• This season, Louisville has been moneyline favorites 16 times and won 13, or 81.2%, of those games.
• The Cardinals have been at least a -442 moneyline favorite eight times this season and won each of those games.
• The moneyline for this contest implies a 81.5% chance of a victory for Louisville.
• SMU has come away with two wins in the seven contests it has been listed as the moneyline underdog this season.
• The Mustangs have been listed as an underdog of +337 or more on two occasions this season and lost both games.
• SMU has an implied victory probability of 22.9% according to the moneyline set by oddsmakers for this matchup.