49ers vs. Cardinals Week 3 Dunkel NFL Picks, Predictions and Odds

The San Francisco 49ers (2-0) and Arizona Cardinals (1-1) will play each other in a matchup of two division rivals. The 49ers are solid favorites, expected to win by at least a touchdown (currently -7.5). The expected point total for the game is 48.5.

The 49ers are putting up 380.5 yards per game offensively this year (eighth in NFL), and they are surrendering 287.0 yards per game (ninth) on the defensive side of the ball. From an offensive perspective, the Cardinals are posting 272.0 total yards per contest (27th-ranked). They rank 13th in the NFL on defense (324.5 total yards surrendered per game).

49ers vs. Cardinals Odds and Game Time

• Date: Sunday, September 27, 2026
• Time: 4:05 p.m. ET
• City: Santa Clara, California
• Venue: Levi's Stadium
• Total: 48.5 points
• Spread: 49ers -7.5
• Moneyline: 49ers (-395), Cardinals (+310)

How to watch 49ers vs. Cardinals

• TV Channel: FOX

Betting the Over/Under: 49ers vs. Cardinals

• Games featuring San Francisco have hit the over once this season.
• Arizona and its opponent have not yet hit the over in 2026.
• These two teams are scoring 47.5 points per game between them, 1.0 fewer than this matchup's total.
• Opponents of these teams average 32.5 points per game combined, 16.0 fewer than this matchup's over/under.

Betting the Spread: 49ers vs. Cardinals

• San Francisco has covered twice in two chances against the spread this season.
• San Francisco has covered the spread when playing as at least 7.5-point favorites in their only opportunity this season.
• The Cardinals have covered once in two games ATS this year.
• Arizona has won its only game this season when playing as at least 7.5-point underdogs.

Betting the Moneyline: 49ers vs. Cardinals

• San Francisco has been the moneyline favorite only one other time so far this season, a game they won.
• The Cardinals have split the two games they've played as underdogs this season.
• San Francisco has played as a moneyline favorite of -395 or shorter in just one game this season, which it won.
• Arizona has played as an underdog of +310 or more once this season and won that game.
• Based on this contest's moneyline, the 49ers' implied win probability is 79.8%.

Dunkel Prediction for 49ers vs. Cardinals

For more expert NFL picks, visit our Dunkel Index NFL Picks and Predictions.