49ers vs. Cardinals Week 3 Dunkel NFL Picks, Predictions and Odds

The San Francisco 49ers (2-0) and Arizona Cardinals (1-1) will play each other in a battle of two division rivals. The 49ers are solid favorites, expected to win by at least a touchdown (currently -9.5). The expected point total for the game is 48.5.

The 49ers rank eighth in total offense (380.5 yards per game) and 10th in total defense (287.0 yards allowed per game) this season. From an offensive perspective, the Cardinals are posting 272.0 total yards per game (26th-ranked). They rank 14th in the NFL defensively (324.5 total yards given up per game).

49ers vs. Cardinals Odds and Game Time

• Date: Sunday, September 27, 2026
• Time: 4:05 p.m. ET
• City: Santa Clara, California
• Venue: Levi's Stadium
• Total: 48.5 points
• Spread: 49ers -9.5
• Moneyline: 49ers (-455), Cardinals (+350)

How to watch 49ers vs. Cardinals

• TV Channel: FOX

Betting the Over/Under: 49ers vs. Cardinals

• So far this season, one San Francisco game has hit the over.
• So far this year, no Arizona game has hit the over.
• The two teams combine to score 47.5 points per game, 1.0 fewer point than this matchup's over/under.
• These teams give up a combined 32.5 points per game, 16.0 fewer points than this matchup's total.

Betting the Spread: 49ers vs. Cardinals

• San Francisco has won two games against the spread this season.
• San Francisco has covered the spread when playing as at least 9.5-point favorites in their only opportunity this season.
• The Cardinals have a record of 1-1-0 against the spread this year.
• Arizona has been an underdog by 9.5 points or more once this season, and covered the spread.

Betting the Moneyline: 49ers vs. Cardinals

• San Francisco has been listed as the moneyline favorite only one other time so far this season, a game they won.
• The Cardinals have split the two games they've played as underdogs this season.
• San Francisco has played as a moneyline favorite of -455 or shorter in just one game this season, which it won.
• Arizona has played as an underdog of +350 or more once this season and won that game.
• The 49ers have an implied moneyline win probability of 82.0% in this game.

Dunkel Prediction for 49ers vs. Cardinals

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