Padres vs. Diamondbacks Dunkel MLB Picks, Predictions and Prop Bets - Sept. 25

Nolan Arenado brings a 10-game hitting streak into the Arizona Diamondbacks' game versus the San Diego Padres, at 9:40 p.m. ET on Friday, at Petco Park. Casey Mize (6-9, 3.96 ERA) gets the start for the Padres, who are 89-70 this season and second in the NL West. Brandon Pfaadt (7-3, 3.72 ERA) is the expected starter for the Diamondbacks, who are 85-74 and third in the NL West.

The Padres (-136) are moneyline favorites at home over the Diamondbacks (+112). The game has an over/under of 7.5 runs.

Padres vs. Diamondbacks Odds, Game Time

• Game day: Friday, September 25, 2026
• Game time: 9:40 p.m. ET
• Location: San Diego, California
• Stadium: Petco Park
• Favorite: Padres (-136)
• Underdog: Diamondbacks (+112)
• Over/under: 7.5

How to Watch Padres vs. Diamondbacks

• TV Channel: SDPA and ARID
• Live Stream: Fubo (Watch for free)

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Padres vs. Diamondbacks: Betting the Moneyline

• The Padres have been the moneyline favorite 79 total times this season. They've gone 49-30 in those games.
• Arizona has come away with 42 wins in the 86 contests it has been listed as the underdogs in this season.
• San Diego has a record of 33-11 in games when sportsbooks favor them by at least -136 on the moneyline.
• The Diamondbacks have a mark of 24-25 in contests where bookmakers favor them by +112 or worse on the moneyline.
• Based on this game's moneyline, the Padres' implied win probability is 57.6%.
• Oddsmakers have implied with the moneyline set for this matchup that the Diamondbacks have a 47.2% chance of pulling out a win.

Padres vs. Diamondbacks: Betting the Spread & Total

• The Padres have had an over/under set by oddsmakers 159 times, and have combined with opponents to go over the total in 74 of those games (74-80-5).
• Games involving Arizona have gone over the total set by sportsbooks in 69 of 159 chances this season.
• The Padres have covered 56.6% of their games this season, going 90-69-0 ATS.
• The Diamondbacks have an against the spread mark of 85-74-0 in 159 games with a line this season.