Astros vs. Athletics Dunkel MLB Picks, Predictions and Prop Bets - Sept. 25

Lucas Spence leads the Houston Astros into a contest versus the Athletics after his three-homer outing in a 7-5 victory over the Athletics. The game begins at 9:40 p.m. ET on Friday. Hunter Brown (6-3, 3.26 ERA) will start for the Astros, who are 79-80 this season and first in the AL West. Jacob Lopez (6-5, 5.68 ERA) is expected to start for the Athletics, who are 63-96 and fourth in the AL West.

Despite playing on the road, the Astros are still a decent moneyline favorite (-182) over the Athletics (+148). The total for the Astros-Athletics game is set at 9.

Astros vs. Athletics Odds, Game Time

• Game day: Friday, September 25, 2026
• Game time: 9:40 p.m. ET
• Location: West Sacramento, California
• Stadium: Sutter Health Park
• Favorite: Astros (-182)
• Underdog: Athletics (+148)
• Over/under: 9

How to Watch Astros vs. Athletics

• TV Channel: NBCS-CA and SCHN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Astros vs. Athletics: Betting the Moneyline

• The Astros have gone 34-34 in games they were favored on the moneyline (winning 50% of those games).
• The Athletics have been chosen as underdogs in 123 games this year and have walked away with the win 47 times (38.2%) in those games.
• The Astros have a record of 2-5 when they're favored by -182 or more by sportsbooks this season.
• This season, the Athletics have come away with a win 10 times in 39 chances when named as an underdog of at least +148 or worse on the moneyline.
• The implied moneyline probablility for this matchup gives the Astros a 64.5% chance to win.
• The Athletics have an implied victory probability of 40.3% according to the moneyline set for this matchup.

Astros vs. Athletics: Betting the Spread & Total

• The Astros have combined with their opponents to go over the total 77 times this season for a 77-72-10 record against the over/under.
• The Athletics and their opponents have hit the over in 82 of their 159 games with a total this season.
• The Astros have collected an 83-76-0 record against the spread this season (covering 52.2% of the time).
• The Athletics are 76-83-0 against the spread in their 159 games with a line set by sportsbooks this season.