Louisville vs. Jackson State Dunkel Predictions & Vegas Odds - Nov. 6

The No. 11 Louisville Cardinals (1-0) host the Jackson State Tigers (0-1) at KFC Yum! Center, beginning at 7 p.m. ET on Thursday, November 6, 2025. The Cardinals are 32.5-point favorites in the game. The matchup has an over/under of 162.5.

Louisville enters this matchup on the heels of a 104-45 victory over South Carolina State on Monday. Khani Rooths' team-leading 20 points led Louisville in the victory. Jackson State heads into this game on the heels of a 113-55 loss to Illinois on Monday. Jackson State got a team-high 19 points from Devin Ree in the loss.

Louisville vs. Jackson State Odds and Game Time

• When: Thursday, November 6, 2025 at 7 p.m. ET
• Where: KFC Yum! Center in Louisville, Kentucky
• Spread favorite: Louisville -32.5
• Over/Under: 162.5 points

How to watch Louisville vs. Jackson State

• TV Channel: ACC Network Extra
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Louisville vs. Jackson State

• Louisville's games went over 162.5 points scored, its current matchup's point total, seven times (out of 35) last year.
• Jackson State's games went over 162.5 total points scored in seven of 34 matchups last season.
• The Cardinals and the Tigers combined to average 12.6 fewer points per game a season ago than the total of 162.5 set for this matchup.
• The Cardinals and the Tigers saw their opponents average a combined 18.4 fewer points per game last season than the point total of 162.5 set in this outing.
• Louisville's average point total in matchups last year was 148.0, 14.5 points below the total in this game.
• The average total in Jackson State's games in 2024 was 16.5 fewer points than the point total of 162.5 in this game.

Betting the Spread: Louisville vs. Jackson State

• Louisville went 20-15-0 ATS last season.
• Jackson State won 20 games against the spread last season, while failing to cover 14 times.
• The Tigers did not cover the spread when an underdog by 32.5 points or more last year (in three opportunities).
• At home last year, Louisville was 14-3 overall and 8-9 against the spread.
• Jackson State was 11-10 against the spread, and 6-15 overall, in away games last season.