Rams vs. 49ers Week 10 Dunkel NFL Picks, Predictions and Odds

The Los Angeles Rams (6-2) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -4.5) over the San Francisco 49ers (6-3). The Rams have taken three games straight. The predicted point total for the matchup is 49.5.

The Rams are averaging 369.9 yards per game on offense, which ranks them seventh in the NFL. On the defensive side of the ball, they rank 10th, surrendering 302.9 yards per contest. From an offensive standpoint, the 49ers are compiling 21.6 points per contest (23rd-ranked). They rank ninth in the NFL on the other side of the ball (20.9 points allowed per game).

Rams vs. 49ers Odds and Game Time

• Date: Sunday, November 9, 2025
• Time: 4:25 p.m. ET
• City: Santa Clara, California
• Venue: Levi's Stadium
• Total: 49.5 points
• Spread: Rams -4.5
• Moneyline: Rams (-225), 49ers (+185)

How to watch Rams vs. 49ers

• TV Channel: FOX (KNIN-Boise, ID)
• Live Stream: Fubo

Betting the Over/Under: Rams vs. 49ers

• In two games this season, the Rams and their opponents have combined to score more than 49.5 points.
• In Los Angeles' eight games this season, the combined scoring has gone over the point total three times.
• The 49ers have combined with their opponent to score more than 49.5 points just once this season.
• San Francisco games have gone over the point total five out of nine times this season.
• The teams average 47.7 points per game combined, 1.8 fewer than this matchup's total.
• These two teams together surrender 36.8 points per game, 12.7 fewer than this matchup's over/under.

Betting the Spread: Rams vs. 49ers

• Los Angeles has compiled a 6-2-0 ATS record so far this year.
• Los Angeles has covered the spread three times this season (3-1 ATS) when playing as at least 4.5-point favorites.
• The 49ers have covered five times in nine chances against the spread this season.
• San Francisco has been an underdog by 4.5 points or more once this season, and covered the spread.
• At home this year, the 49ers have one win against the spread and are 2-1 overall.
• This year away from home, the Rams are 3-1 against the spread and 3-1 overall.
• Los Angeles is unbeaten ATS (2-0) away from home as 4.5-point favorites or more.

Betting the Moneyline: Rams vs. 49ers

• Los Angeles has a 6-1 record in games they were favored on the moneyline (winning 85.7% of those games).
• The 49ers have won one of the three games they've played as underdogs this season.
• Los Angeles has a record of 3-1 when playing as a moneyline favorite with odds of -225 or shorter (75%).
• San Francisco has played as an underdog of +185 or more once this season and won that game.
• Based on this contest's moneyline, the Rams' implied win probability is 69.2%.

Dunkel Prediction for Rams vs. 49ers

For more expert NFL picks, visit our Dunkel Index NFL Picks and Predictions.