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Tigers vs. Guardians Dunkel MLB Picks, Predictions and Prop Bets - Sept. 16

MLB Previews

16 September 2025 By Data Skrive

The Cleveland Guardians aim to extend their four-game winning streak when they face the Detroit Tigers on Tuesday at 6:40 p.m. ET, at Comerica Park. Casey Mize (14-5, 3.83 ERA) will start for the Tigers, who are 85-65 this season and first in the AL Central. Joey Cantillo (5-3, 3.36 ERA) is the expected starter for the Guardians, who are 78-71 and second in the AL Central.

With the Guardians (+119) visiting, the Tigers (-142) are a solid favorite on the moneyline. The game has an over/under set at 8 runs.

Tigers vs. Guardians Odds, Game Time

Game day: Tuesday, September 16, 2025
Game time: 6:40 p.m. ET
Location: Detroit, Michigan
Stadium: Comerica Park
Favorite: Tigers (-142)
Underdog: Guardians (+119)
Over/under: 8

How to Watch Tigers vs. Guardians

TV Channel: Cleveland Guardians (NEW)
Live Stream: Fubo (Watch for free)

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Tigers vs. Guardians: Betting the Moneyline

The Tigers have gone 63-41 in games they were favored on the moneyline (winning 60.6% of those games).
Cleveland has been underdogs in 82 games this season and has come away with the win 37 times (45.1%) in those contests.
This season Detroit has won 44 of its 64 games, or 68.8%, when favored by at least -142 on the moneyline.
The Guardians have a mark of 20-17 in contests where bookmakers favor them by +119 or worse on the moneyline.
The Tigers have an implied moneyline win probability of 58.7% in this game.
The moneyline set for this matchup implies the Guardians have a 45.7% chance of coming away with a victory in the contest.

Tigers vs. Guardians: Betting the Spread & Total

The Tigers have combined with opponents to hit the over on the total 79 times this season for a 79-64-7 record against the over/under.
Cleveland and its opponents have hit the over in 62 of its 147 games with a total this season.
The Tigers have a 72-78-0 record ATS this season (covering 48% of the time).
In 147 games with a line this season, the Guardians have a mark of 76-71-0 against the spread.

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About the author

Data Skrive

Data Skrive creates sports articles about every player, on every team, in every league, for every game, for every fan. Data Skrive know sports. With over 100M monthly readers across 500+ websites and 200+ DMAs, their innovative Fan Engagement Solution creates engaging and entertaining sports content that fans value to drive revenue for their customers. Sports never stop, and covering every topic at the right time is not feasible. Data Skrive's technology is able to cover highly relevant topics that are interesting and engaging to your fans.