Diamondbacks vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - Sept. 16
16 September 2025

The Arizona Diamondbacks aim to continue their three-game win streak when they face the San Francisco Giants on Tuesday at 9:40 p.m. ET, at Chase Field. The Diamondbacks are 76-75 this season, third in the NL West. The Giants are 75-75, fourth in the NL West. Neither team has named a starter.
The Giants (+109) take their show on the road to face the favored Diamondbacks (-129). The over/under for this contest is set at 9.
Diamondbacks vs. Giants Odds, Game Time
- Game day: Tuesday, September 16, 2025
- Game time: 9:40 p.m. ET
- Location: Phoenix, Arizona
- Stadium: Chase Field
- Favorite: Diamondbacks (-129)
- Underdog: Giants (+109)
- Over/under: 9
How to Watch Diamondbacks vs. Giants
- TV Channel: Arizona Diamondbacks (NEW)
- Live Stream: Fubo (Watch for free)
Diamondbacks vs. Giants: Betting the Moneyline
- The Diamondbacks have won 44 of the 85 games they were the moneyline favorite this season (51.8%).
- San Francisco has been pegged as an underdog in 62 games this year and has walked away with the win 29 times (46.8%) in those games.
- Arizona has entered 52 games this season favored by -129 or more and is 27-25 in those contests.
- This year, the Giants have won 19 of 42 games when listed as at least +109 or worse on the moneyline.
- Based on this contest's moneyline, the Diamondbacks have an implied win probability of 56.3%.
- The moneyline set for this matchup implies the Giants have a 47.8% chance of coming away with a victory in the contest.
Diamondbacks vs. Giants: Betting the Spread & Total
- The Diamondbacks have played in 150 games with a set over/under, and have combined with their opponents to go over the total 72 times (72-69-9).
- San Francisco and its opponents have hit the over in 70 of its 150 games with a total this season.
- The Diamondbacks have collected a 78-72-0 record ATS this season (covering 52% of the time).
- In 150 games with a line this season, the Giants have a mark of 69-81-0 against the spread.