TCU vs. Iowa State Dunkel NCAA Football Picks, Predictions and Odds - Nov. 8

The TCU Horned Frogs (6-2) host the Iowa State Cyclones (5-4) on Saturday, November 8, 2025 in a matchup between Big 12 foes at Amon G. Carter Stadium. Iowa State is a 6.5-point underdog.

In their last game, the Horned Frogs won against the West Virginia Mountaineers, 23-17.

The Cyclones' most recent game was versus the Arizona State Sun Devils, and they lost by a score of 24-19.

TCU vs. Iowa State Predictions

Ahead of the upcoming game between the TCU Horned Frogs and Iowa State Cyclones, computer-derived against-the-spread, over/under, and score predictions are below, per Dunkel Index.

• Pick ATS: Cyclones (+ 6.5)
• Pick OU: Over (57.5)
  
• Prediction: Horned Frogs 33 - Cyclones 30

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TCU vs. Iowa State Moneylines

Snag a peek below at the latest moneylines for the Horned Frogs-Cyclones matchup.

• TCU Moneyline: -256
• Iowa State Moneyline: +205

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TCU Betting Insights

• TCU has won five of the six games it was the moneyline favorite this season (83.3%).
• TCU has played as a moneyline favorite of -256 or shorter in just two games this season, and it won both.
• The Horned Frogs and their opponents have scored more than 57.5 points in five of eight games this season.
• The Horned Frogs have an average point total of 58.4 in their outings this year, 0.9 more points than this matchup's over/under.
• The Cyclones are college football's 64th-highest scoring team this season compared to the 39th-ranked Horned Frogs.

Iowa State Betting Insights

• Iowa State has split the two games it has played as underdogs this season.
• Iowa State has not entered a game this season with longer moneyline odds than +205.
• Iowa State has played three games this season that have had more than 57.5 combined points scored.
• Iowa State's outings this season have a 50.2-point average over/under, 7.3 fewer points than this game's total.

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Key Stats for TCU vs. Iowa State

• Over their last three meetings, Iowa State has put up two wins against TCU.
• The Cyclones own a 2-1 record ATS in those games, while the two teams have gone over the total on two occasions.
• Offensively, the Horned Frogs rank 39th in the FBS with 425.5 yards per game. Meanwhile, they rank 79th in total defense (378.0 yards allowed per contest).
• TCU is averaging 34.6 points per game offensively this year (29th in the FBS), and is allowing 25.1 points per game (74th) on defense.
• The Cyclones rank 60th with 407.6 total yards per contest on offense, and they rank 63rd with 366.0 total yards surrendered per game on the defensive side of the ball.
• With 27.9 points per game on offense, Iowa State ranks 73rd in the FBS. On defense, it ranks 46th, allowing 22.0 points per game.