Seahawks vs. Cardinals Week 10 Dunkel NFL Picks, Predictions and Odds

The Seattle Seahawks (6-2) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -6.5) over the Arizona Cardinals (3-5). The Seahawks have won three games in a row. The game has an over/under of 46.5 points.

The Seahawks have been a tough matchup for opposing teams, as they rank top-five in both scoring offense (fifth-best with 28.9 points per game) and scoring defense (fifth-best with 18.8 points allowed per game) this season. In terms of total yards, the Cardinals rank 21st in the NFL (314 total yards per game) and 20th on defense (335.4 total yards allowed per game).

Seahawks vs. Cardinals Odds and Game Time

• Date: Sunday, November 9, 2025
• Time: 4:05 p.m. ET
• City: Seattle, Washington
• Venue: Lumen Field
• Total: 46.5 points
• Spread: Seahawks -6.5
• Moneyline: Seahawks (-305), Cardinals (+245)

How to watch Seahawks vs. Cardinals

• TV Channel: CBS (KOIN-Portland, OR)
• Live Stream: Fubo

Betting the Over/Under: Seahawks vs. Cardinals

• The Seahawks and their opponents have combined to score more than 46.5 points in four of eight games this season.
• So far this season, five of Seattle's eight games have gone over the point total.
• The Cardinals have played three games this season that have had more than 46.5 combined points scored.
• Arizona and its opponent have combined to hit the over four out of eight times this year.
• These teams score 51.4 points per game combined, 4.9 more than this game's over/under.
• Opponents of these teams average 40.2 points per game combined, 6.3 fewer than this matchup's over/under.

Betting the Spread: Seahawks vs. Cardinals

• Seattle has covered the spread six times in eight games this season.
• Seattle has won their only game this season when playing as at least 6.5-point favorites.
• The Cardinals are 5-3-0 ATS this year.
• Arizona has been an underdog by 6.5 points or more two times this season, and covered the spread both times.
• At home this year, the Seahawks have two wins against the spread and are 2-2 overall.
• At home, as 6.5-point favorites or greater, Seattle is unbeaten ATS (1-0).
• In away games, the Cardinals are 4-0 against the spread and 2-2 overall.
• Arizona is unbeaten ATS (1-0) on the road as 6.5-point underdogs or more.

Betting the Moneyline: Seahawks vs. Cardinals

• Seattle has been the moneyline favorite six total times this season. They've finished 5-1 in those games.
• The Cardinals have been underdogs in five games this season and won one (20%) of those contests.
• Seattle has played as a moneyline favorite of -305 or shorter in just one game this season, which it won.
• Arizona has been at least a +245 moneyline underdog two times this season, but lost all of those games.
• The Seahawks have a 75.3% chance to win this matchup based on the moneyline's implied probability.

Dunkel Prediction for Seahawks vs. Cardinals

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