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Giants vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - Sept. 22

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22 September 2025 By Data Skrive

The San Francisco Giants host the St. Louis Cardinals to open a three-game series at Oracle Park, with first pitch at 9:45 p.m. ET on Monday. Justin Verlander (3-10, 3.75 ERA) will start for the Giants, who are 77-79 this season and fourth in the NL West. Michael McGreevy (7-3, 4.08 ERA) is the expected starter for the Cardinals, who are 76-80 and fourth in the NL Central.

With the Cardinals (+124) visiting, the Giants (-148) are a solid favorite on the moneyline. The contest has a total set at 8.

Giants vs. Cardinals Odds, Game Time

Game day: Monday, September 22, 2025
Game time: 9:45 p.m. ET
Location: San Francisco, California
Stadium: Oracle Park
Favorite: Giants (-148)
Underdog: Cardinals (+124)
Over/under: 8

How to Watch Giants vs. Cardinals

TV Channel: NBC Sports Bay Area
Live Stream: Fubo (Watch for free)

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Giants vs. Cardinals: Betting the Moneyline

The Giants have won 46 of the 87 games they were listed as the moneyline favorite this season (52.9%).
St. Louis has been underdogs in 88 games this season and has come away with the win 42 times (47.7%) in those contests.
San Francisco has entered 44 games this season favored by -148 or more and is 23-21 in those contests.
This season, the Cardinals have been victorious 12 times in 33 chances when named as an underdog of at least +124 or worse on the moneyline.
The Giants have an implied moneyline win probability of 59.7% in this matchup.
The moneyline set for this matchup implies the Cardinals have a 44.6% chance of walking away with the win.

Giants vs. Cardinals: Betting the Spread & Total

In the 156 games in which oddsmakers have set an over/under for the Giants, they have combined with opponents to go over the total 72 times (72-74-10).
St. Louis' games have gone over the total in 77 of its 155 chances.
The Giants have covered 46.8% of their games this season, going 73-83-0 against the spread.
In 155 games with a line this season, the Cardinals have a mark of 79-76-0 against the spread.

Dunkel Index Prediction for Giants vs. Cardinals

Pick OU: Under (8)
Prediction: Cardinals 4 - Giants 3

Check out all the Dunkel Index MLB Baseball Picks!

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About the author

Data Skrive

Data Skrive creates sports articles about every player, on every team, in every league, for every game, for every fan. Data Skrive know sports. With over 100M monthly readers across 500+ websites and 200+ DMAs, their innovative Fan Engagement Solution creates engaging and entertaining sports content that fans value to drive revenue for their customers. Sports never stop, and covering every topic at the right time is not feasible. Data Skrive's technology is able to cover highly relevant topics that are interesting and engaging to your fans.