49ers vs. Cowboys Week 10 Dunkel NFL Picks, Predictions and Odds

The San Francisco 49ers (7-1) are considered favorites (-3.5) according to the oddsmakers ahead of their game against the Dallas Cowboys (4-5) on November 15, 2026, starting at 4:25 p.m. ET, airing on FOX. The matchup has an over/under of 55.5 points.

On defense, the 49ers have been a top-five unit, ranking third-best by surrendering only 291.9 yards per game. They rank sixth on offense (376.8 yards per game). The Cowboys rank 10th in total yards per game (360.4), but they've been worse on the other side of the ball, ranking third-worst in the NFL with 372.7 total yards allowed per contest.

49ers vs. Cowboys Odds and Game Time

• Date: Sunday, November 15, 2026
• Time: 4:25 p.m. ET
• City: Arlington, Texas
• Venue: AT&T Stadium
• Total: 55.5 points
• Spread: 49ers -3.5
• Moneyline: 49ers (-205), Cowboys (+170)

How to watch 49ers vs. Cowboys

• TV Channel: FOX

Betting the Over/Under: 49ers vs. Cowboys

• The 49ers and their opponents have combined to score more than 55.5 points two times this season (in eight games).
• A total of four out of eight San Francisco games this season have gone over the point total.
• The Cowboys have played five games this season that ended with a combined score over 55.5 points.
• In 2026, five Dallas games have hit the over.
• The teams average 56.7 points per game combined, 1.2 more points than this game's total.
• These teams allow a combined 45.7 points per game, 9.8 fewer points than this contest's total.

Betting the Spread: 49ers vs. Cowboys

• San Francisco has compiled a 5-3-0 record against the spread this season.
• San Francisco has covered the spread twice this season (2-2 ATS) when playing as at least 3.5-point favorites.
• The Cowboys have won five games against the spread this season, failing to cover four times.
• Dallas has covered the spread when playing as at least 3.5-point underdogs in its only opportunity this season.
• At home this season, the Cowboys have two wins against the spread and are 1-3 overall.
• Dallas is unbeaten ATS (1-0) as 3.5-point underdogs or more at home.
• On the road, the 49ers have two wins against the spread and are 2-1 overall.

Betting the Moneyline: 49ers vs. Cowboys

• San Francisco has won 83.3% of the games this season when it was the moneyline favorite (5-1).
• The Cowboys have split the two games they've played as underdogs this season.
• San Francisco has played four times as a moneyline favorite with odds of -205 or shorter, and earned a victory in each game.
• Dallas has not entered a game this season with longer moneyline odds than +170.
• The 49ers have a 67.2% chance to win this game based on the moneyline's implied probability.

Dunkel Prediction for 49ers vs. Cowboys

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