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Padres vs. Brewers Dunkel MLB Picks, Predictions and Prop Bets - Sept. 22

MLB Previews

22 September 2025 By Data Skrive

The San Diego Padres host the Milwaukee Brewers at 9:40 p.m. ET on Monday, in a matchup of two hurlers with top-10 ERAs. Nick Pivetta (2.81 ERA) gets the start for the Padres, while the Brewers will go with Freddy Peralta (2.65). Pivetta (13-5, 2.81 ERA) gets the start for the Padres, who are 85-71 this season and second in the NL West. Peralta (17-6, 2.65 ERA) is expected to start for the Brewers, who are 95-61 and first in the NL Central.

With the Brewers (+100) visiting, the Padres (-120) are a solid favorite on the moneyline. The total for the Padres-Brewers game is set at 7.

Padres vs. Brewers Odds, Game Time

Game day: Monday, September 22, 2025
Game time: 9:40 p.m. ET
Location: San Diego, California
Stadium: PETCO Park
Favorite: Padres (-120)
Underdog: Brewers (+100)
Over/under: 7

How to Watch Padres vs. Brewers

TV Channel: FanDuel Sports Network Midwest Extra - Iowa
Live Stream: Fubo (Watch for free)

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Padres vs. Brewers: Betting the Moneyline

The Padres have put together a 52-36 record in games they were listed as the moneyline favorite (winning 59.1% of those games).
Milwaukee has come away with 35 wins in the 63 contests it has been listed as the underdogs in this season.
San Diego has entered 81 games this season favored by -120 or more and is 48-33 in those contests.
This season, the Brewers have come away with a win 25 times in 48 chances when named as an underdog of at least +100 or longer on the moneyline.
The Padres have a 54.5% chance to win this game based on the moneyline's implied probability.
The moneyline set for this matchup implies the Brewers have a 50% chance of coming away with a victory in the contest.

Padres vs. Brewers: Betting the Spread & Total

The Padres have played in 156 games with over/under set, and have combined with opponents to go over the total 66 times (66-84-6).
Milwaukee's games have gone over the total in 75 of its 156 chances.
The Padres have an 83-73-0 record against the spread this season.
The Brewers have posted a record of 87-69-0 against the spread this season.