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Sabres vs. Bruins NHL Predictions, Picks and Odds - March 25

25 March 2026 By Data Skrive

The Buffalo Sabres and Boston Bruins -- both coming off losses -- will face each other on Wednesday at 7:30 p.m. ET, at KeyBank Center in Buffalo. The oddsmakers have made the Sabres solid favorites at -218 on the moneyline, and the Bruins are at +180.

Buffalo's last game was a 6-5 overtime road loss against the Anaheim Ducks on March 22. The Sabres got two points apiece out of three skaters, including Rasmus Dahlin (two assists) and Zachary Benson (one goal and one assist).

Boston lost 4-2 at home against the Toronto Maple Leafs in its last game on March 24. The Bruins got one point apiece out of six skaters in that outing, including Charlie McAvoy (one goal) and Elias Lindholm (one goal).

Before this matchup, here is who we project to emerge victorious in Wednesday's hockey action.

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Sabres vs. Bruins Predictions & Pick

For the upcoming game between the Buffalo Sabres and Boston Bruins, computer-calculated moneyline, over/under, and score predictions are below, per Dunkel Index.

  • Prediction: Sabres 5 - Bruins 2
  • Pick OU: Over 6.5 (Dunkel projecting 7.00 goals)

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Sabres vs. Bruins Moneylines

Take a look below at the most recent moneylines for the Sabres-Bruins game.

  • Favorite: Sabres (-218)
  • Underdog: Bruins (+180)

Sabres Betting Insights

  • In the 34 times this season the Sabres have been a moneyline favorite, they have finished 22-12 in those games.
  • Buffalo has been a moneyline favorite of -218 or shorter in just two games this season, and split them 1-1.
  • Based on the moneyline in this contest, the Sabres' implied win probability is 68.6%.
  • In 32 games this season, Buffalo and its opponent have combined for more than 6.5 goals.

Bruins Betting Insights

  • The Bruins have been listed as an underdog 45 times this season, and won 22, or 48.9%, of those games.
  • This season Boston has been at least a +180 underdog on the moneyline four times, losing each of those contests.
  • The oddsmakers' moneyline implies a 35.7% chance of victory for the Bruins.
  • Boston has played 37 games this season that finished with more than 6.5 goals.

Sabres Key Stats

  • Buffalo's 247 total goals (3.5 per game) make it the fourth-highest scoring team in the league.
  • Defensively, the Sabres are one of the stingiest units in NHL action, allowing 207 total goals (2.9 per game) to rank eighth.
  • Its goal differential (+40) makes the team fourth-best in the league.
  • The 43 power-play goals the Sabres have put up this season (on 211 power-play chances) rank 15th in the NHL.
  • Buffalo has the league's 16th-ranked power-play conversion rate (20.38%).
  • The Sabres have scored 10 shorthanded goals this season.
  • Buffalo has the league's sixth-best penalty-kill percentage (81.87%).
  • Buffalo has the 32nd-ranked faceoff win percentage in the NHL, at 45.4%.
  • The Sabres make 12.4% of their shots (fourth in the league).

Bruins Key Stats

  • Boston's 233 goals on the season (3.3 per game) rank 10th in the NHL.
  • The Bruins' total of 218 goals given up (3.1 per game) is 20th in the league.
  • With a goal differential of +15, the team is 11th in the league.
  • The Bruins have 51 power-play goals (fifth-most in NHL) on 215 chances.
  • Boston's power-play percentage (23.72) puts the team eighth in the league.
  • This season, the Bruins have two shorthanded goals (29th in NHL).
  • At 77.29%, Boston has the 25th-ranked penalty-kill percentage in the league.
  • Boston is fifth in faceoff win percentage in the NHL (52.6%).
  • The 12.1% shooting percentage of the Bruins is fifth in the league.

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