Astros vs. Guardians Dunkel MLB Picks, Predictions and Prop Bets - June 21

The Houston Astros and Cleveland Guardians play a rubber match on Sunday at 2:10 p.m. ET, with the series deadlocked at 1-1. Kai-Wei Teng (3-6, 4.31 ERA) gets the start for the Astros, who are 36-42 this season and fourth in the AL West. Slade Cecconi (3-5, 4.60 ERA) is expected to start for the Guardians, who are 41-36 and first in the AL Central.

With the Guardians (+114) visiting, the Astros (-138) are a solid favorite on the moneyline. The contest has a total set at 8.5.

Astros vs. Guardians Odds, Game Time

• Game day: Sunday, June 21, 2026
• Game time: 2:10 p.m. ET
• Location: Houston, Texas
• Stadium: Daikin Park
• Favorite: Astros (-138)
• Underdog: Guardians (+114)
• Over/under: 8.5

How to Watch Astros vs. Guardians

• TV Channel: SCHN and CLEG
• Live Stream: Fubo (Watch for free)

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Astros vs. Guardians: Betting the Moneyline

• The Astros have compiled an 11-16 record in games they were listed as the moneyline favorite (winning 40.7% of those games).
• Cleveland has been underdogs in 37 games this season and has come away with the win 20 times (54.1%) in those contests.
• Houston is 5-8 this season when entering a game favored by -138 or more on the moneyline.
• This season, the Guardians have come away with a win 13 times in 23 chances when named as an underdog of at least +114 or longer on the moneyline.
• Based on this contest's moneyline, the Astros have an implied win probability of 58%.
• The Guardians have an implied victory probability of 46.7% according to the moneyline set by oddsmakers for this matchup.

Astros vs. Guardians: Betting the Spread & Total

• The Astros have combined with opponents to hit the over on the total 42 times this season for a 42-32-4 record against the over/under.
• Cleveland and its opponents have hit the over in 38 of its 77 games with a total this season.
• The Astros have a 37-41-0 record against the spread this season.
• In 77 games with a line this season, the Guardians have a mark of 40-37-0 against the spread.