Duke vs. UConn Dunkel NCAA Football Picks, Predictions and Odds - Nov. 8

A pair of the nation's best passing offenses square off when the Duke Blue Devils (5-3) take college football's fourth-ranked passing offense into a matchup with the UConn Huskies (6-3), who have the No. 12 passing offense, on Saturday, November 8, 2025. The Blue Devils are 9.5-point favorites.

The Blue Devils won versus the Clemson Tigers in their last game, 46-45.

Facing the UAB Blazers in their most recent game, the Huskies won 38-19.

Duke vs. UConn Predictions

For insights on the upcoming game between the Duke Blue Devils and UConn Huskies, computer-calculated against-the-spread, over/under, and score predictions are below, sourced from Dunkel Index.

• Pick ATS: Huskies (+ 9.5)
• Pick OU: Under (65.5)
  
• Prediction: Blue Devils 34 - Huskies 29

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Duke vs. UConn Moneylines

Take a look below at the most up-to-date moneylines for the Blue Devils-Huskies game.

• Duke Moneyline: -341
• UConn Moneyline: +272

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Duke Betting Insights

• Duke has gone 4-1 in games it was favored on the moneyline (winning 80% of those games).
• Duke has played as a moneyline favorite of -341 or shorter in just one game this season, which it won.
• The Blue Devils and their opponents have gone over 65.5 combined points in three of eight games this season.
• The Blue Devils have had an average of 55.0 points in their games this season, 10.5 fewer than this matchup's total.
• The Blue Devils score the 33rd-most points in college football this season, while the Huskies' offense puts up the ninth-most.

UConn Betting Insights

• UConn lost the only game it has played as the underdog this season.
• UConn has not entered a game this season as a bigger underdog on the moneyline than the +272 odds on them winning this game.
• UConn has played three games this season that ended with a combined score higher than 65.5 points.
• The average total for UConn's games this season is 54.3 points, 11.2 fewer points than this game's over/under.

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Key Stats for Duke vs. UConn

• Duke has a 2-0 record against UConn in their last two matchups.
• In their past two matchups, each team has covered one time with those contests going over the point total on one occasion.
• The Blue Devils rank 102nd in total defense this year (398.9 yards allowed per game), but they've been thriving on offense, ranking 18th-best in the FBS with 460.3 total yards per game.
• Duke sports the 95th-ranked defense this year (28.1 points allowed per game), and has been better offensively, ranking 24th-best with 35.4 points per game.
• The Huskies' offense has been thriving, posting 455.3 total yards per game (21st-best) this season. Defensively, they rank 95th by surrendering 391.7 total yards per game.
• UConn's defense ranks 61st in the FBS with 23.9 points given up per game, but it has been lifted up by its offense, which ranks 15th-best by posting 36.9 points per contest.