Guardians vs. Twins Dunkel MLB Picks, Predictions and Prop Bets - Sept. 21

The Cleveland Guardians carry a 10-game winning streak into a road contest versus the Minnesota Twins at 2:10 p.m. ET on Sunday. Joey Cantillo (5-3, 3.27 ERA) gets the start for the Guardians, who are 84-71 this season and second in the AL Central. Simeon Woods Richardson (7-4, 4.31 ERA) is starting for the Twins, who are 66-89 and fourth in the AL Central.

Bookmakers have set the Guardians as the moderate moneyline favorites (-142) on the road versus the Twins (+119). The contest has a total set at 8.5.

Guardians vs. Twins Odds, Game Time

• Game day: Sunday, September 21, 2025
• Game time: 2:10 p.m. ET
• Location: Minneapolis, Minnesota
• Stadium: Target Field
• Favorite: Guardians (-142)
• Underdog: Twins (+119)
• Over/under: 8.5

How to Watch Guardians vs. Twins

• TV Channel: Cleveland Guardians (NEW)
• Live Stream: Fubo (Watch for free)

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Guardians vs. Twins: Betting the Moneyline

• The Guardians have a 42-24 record in games they were favored on the moneyline (winning 63.6% of those games).
• Minnesota has won in 24, or 37.5%, of the 64 contests it has been named as odds-on underdogs in this year.
• Cleveland has a record of 13-5, a 72.2% win rate, when favored by -142 or more by bookmakers this season.
• This season, the Twins have come away with a win nine times in 25 chances when named as an underdog of at least +119 or longer on the moneyline.
• Based on this contest's moneyline, the Guardians' implied win probability is 58.7%.
• The moneyline set for this matchup implies the Twins have a 45.7% chance of walking away with the win.

Guardians vs. Twins: Betting the Spread & Total

• The Guardians have played in 153 games with set over/under, and have combined with opponents to go over the total 63 times (63-82-8).
• Games involving Minnesota have gone over the total set by oddsmakers in 72 of 154 chances this season.
• The Guardians have collected an 82-71-0 record against the spread this season (covering 53.6% of the time).
• The Twins are 76-78-0 against the spread in their 154 games that had a posted line this season.

Dunkel Index Prediction for Guardians vs. Twins

• Pick OU: Under (8.5)
  
• Prediction: Twins 4 - Guardians 3
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