Guardians vs. Twins Dunkel MLB Picks, Predictions and Prop Bets - Sept. 12

The Cleveland Guardians and Minnesota Twins clash on Saturday at 4:10 p.m. ET. Daniel Espino (0-0, 2.70 ERA) gets the start for the Guardians, who are 75-73 this season and second in the AL Central. Connor Prielipp (4-7, 5.25 ERA) is starting for the Twins, who are 69-78 and third in the AL Central.

With moneyline odds of -119 for the Guardians versus -103 for the Twins, this game should be a close one. The over/under for the Guardians-Twins game is set at 7.5.

Guardians vs. Twins Odds, Game Time

• Game day: Saturday, September 12, 2026
• Game time: 4:10 p.m. ET
• Location: Minneapolis, Minnesota
• Stadium: Target Field
• Favorite: Guardians (-119)
• Underdog: Twins (-103)
• Over/under: 7.5

How to Watch Guardians vs. Twins

• TV Channel: MNNT and CLEG
• Live Stream: Fubo (Watch for free)

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Guardians vs. Twins: Betting the Moneyline

• The Guardians have a 48-44 record in games they were favored on the moneyline (winning 52.2% of those games).
• Minnesota has come away with 40 wins in the 92 contests it has been listed as the underdogs in this season.
• Cleveland is 41-37 this season when entering a game favored by -119 or more on the moneyline.
• This year, the Twins have won 38 of 84 games when listed as at least -103 or worse on the moneyline.
• The Guardians have an implied moneyline win probability of 54.3% in this contest.
• The moneyline set for this matchup implies the Twins have a 50.7% chance of coming away with a victory in the contest.

Guardians vs. Twins: Betting the Spread & Total

• The Guardians have played in 148 games with set over/under, and have combined with opponents to go over the total 70 times (70-77-1).
• Minnesota and its opponents have gone over the total this season in 80 of its 147 opportunities.
• The Guardians have collected a 70-78-0 record against the spread this season (covering 47.3% of the time).
• The Twins are 78-69-0 against the spread in their 147 games that had a posted line this season.