Reds vs. Cubs Dunkel MLB Picks, Predictions and Prop Bets - Sept. 21

The Chicago Cubs carry a three-game losing streak into a home contest versus the Cincinnati Reds, at 1:40 p.m. ET on Sunday. Andrew Abbott (9-7, 2.88 ERA) will start for the Reds, who are 79-76 this season and third in the NL Central. Jameson Taillon (10-6, 3.93 ERA) is expected to start for the Cubs, who are 88-67 and second in the NL Central.

Oddsmakers expect a close matchup between the Reds (-119 to win) and the Cubs (-100). The game has an over/under of 9 runs.

Reds vs. Cubs Odds, Game Time

• Game day: Sunday, September 21, 2025
• Game time: 1:40 p.m. ET
• Location: Cincinnati, Ohio
• Stadium: Great American Ball Park
• Favorite: Reds (-119)
• Underdog: Cubs (-100)
• Over/under: 9

How to Watch Reds vs. Cubs

• TV Channel: Marquee Sports Network
• Live Stream: Fubo (Watch for free)

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Reds vs. Cubs: Betting the Moneyline

• The Reds have won 36 of the 68 games they were the moneyline favorite this season (52.9%).
• Chicago has come away with 18 wins in the 44 contests it has been listed as the underdogs in this season.
• This season Cincinnati has won 29 of its 55 games, or 52.7%, when favored by at least -119 on the moneyline.
• This season, the Cubs have come away with a win 14 times in 31 chances when named as an underdog of at least -100 or worse on the moneyline.
• Based on this matchup's moneyline, the Reds have an implied win probability of 54.3%.
• Bookmakers have implied with the moneyline set for this matchup that the Cubs have a 50% chance of pulling out a win.

Reds vs. Cubs: Betting the Spread & Total

• The Reds have played in 152 games with set over/under, and have combined with opponents to go over the total 58 times (58-86-8).
• So far this season, Chicago and its opponents have hit the over in 70 of its 155 games with a total.
• The Reds have put together a 79-73-0 record ATS this season (covering 52% of the time).
• The Cubs have an against the spread record of 72-83-0 in 155 games with a line this season.

Dunkel Index Prediction for Reds vs. Cubs

• Pick OU: Under (9)
  
• Prediction: Cubs 4 - Reds 3
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