Cubs vs. White Sox Dunkel MLB Picks, Predictions and Prop Bets - May 15

The Chicago White Sox bring a five-game winning streak into a contest versus the Chicago Cubs, at 7:40 p.m. ET on Friday. Edward Cabrera (3-1, 3.88 ERA) gets the start for the Cubs, who are 28-16 this season and first in the NL Central. Sean Burke (2-3, 3.68 ERA) is starting for the White Sox, who are 22-21 and second in the AL Central.

Despite playing on the road, the Cubs are still a decent moneyline favorite (-136) over the White Sox (+114). The game has an over/under of 8.5 runs.

Cubs vs. White Sox Odds, Game Time

• Game day: Friday, May 15, 2026
• Game time: 7:40 p.m. ET
• Location: Chicago, Illinois
• Stadium: Rate Field
• Favorite: Cubs (-136)
• Underdog: White Sox (+114)
• Over/under: 8.5

How to Watch Cubs vs. White Sox

• TV Channel: CHSN and MARQ
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Cubs vs. White Sox: Betting the Moneyline

• The Cubs have won 20 of the 29 games they were listed as the moneyline favorite this season (69%).
• The White Sox have won in 20, or 52.6%, of the 38 contests they have been named as odds-on underdogs in this year.
• This season, the Cubs have won 13 of their 18 games, or 72.2%, when favored by at least -136 on the moneyline.
• This season, the White Sox have come away with a win 14 times in 29 chances when named as an underdog of at least +114 or worse on the moneyline.
• The implied moneyline probablility in this matchup gives the Cubs a 57.6% chance to win.
• The White Sox have an implied victory probability of 46.7% according to the moneyline set for this matchup.

Cubs vs. White Sox: Betting the Spread & Total

• The Cubs have played in 44 games with a set over/under, and have combined with their opponents to go over the total 24 times (24-18-2).
• Games involving the White Sox have gone over the total set by bookmakers in 24 of 43 chances this season.
• The Cubs are 20-24-0 ATS this season.
• The White Sox have an against the spread record of 25-18-0 in 43 games with a line this season.