Texas Tech vs. Houston Dunkel NCAA Football Picks, Predictions and Odds - Oct. 4

The No. 11 Texas Tech Red Raiders (4-0) and the second-ranked scoring offense will take on the Houston Cougars (4-0) and the 14th-ranked scoring defense on Saturday, October 4, 2025. The Red Raiders are favored by 11.5 points in the outing.

Against the Utah Utes in their last game, the Red Raiders won 34-10.

In their most recent game, the Cougars won versus the Oregon State Beavers, 27-24.

Texas Tech vs. Houston Predictions

For the upcoming contest between the Texas Tech Red Raiders and Houston Cougars, computer-calculated against-the-spread, over/under, and score predictions are below, based on data from Dunkel Index.

• Pick ATS: Red Raiders (- 11.5)
• Pick OU: Over (51.5)
  
• Prediction: Red Raiders 36 - Cougars 18

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Texas Tech vs. Houston Moneylines

Grab a peek below at the most up-to-date moneylines for the Red Raiders-Cougars matchup.

• Texas Tech Moneyline: -469
• Houston Moneyline: +359

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Texas Tech Betting Insights

• Texas Tech has been the moneyline favorite just two other times so far this season, and they won both of the games.
• Texas Tech has played as a moneyline favorite of -469 or shorter in only two games this season, and it won both.
• The Red Raiders and their opponents have gone over 51.5 combined points in three of four games this season.
• Red Raiders games this year have an average point total of 60.5, 9.0 more points than this matchup's over/under.
• The Red Raiders are the 10th-highest scoring team in college football this year. The Cougars have scored the 77th-most points.

Houston Betting Insights

• Houston has not played a game this season while listed as the underdog.
• Houston has not entered a game this season with longer moneyline odds than +359.
• Houston and its opponents have scored more than 51.5 combined points once this season.
• Houston's games this season have had an average of 46.5 points, 5.0 fewer points than this game's point total.

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Key Stats for Texas Tech vs. Houston

• In their past three head-to-head contests, Texas Tech has won against Houston three times.
• In those contests versus Houston, the Red Raiders have covered two times while eclipsing the point total on two occasions.
• The Red Raiders have been making things happen on both sides of the ball this season, as they rank second-best in total offense (573 yards per game) and 11th-best in total defense (239 yards allowed per game).
• Texas Tech has been shining on both offense and defense, ranking second-best in scoring offense (52 points per game) and eighth-best in scoring defense (11.3 points allowed per game).
• The Cougars rank 77th in the FBS with 379.5 total yards per game, but they've been carried by their defense, which ranks 16th-best by surrendering just 265.5 total yards per game.
• Houston's defensive unit has been paving the way for the team, as it ranks 14th-best in the FBS with 13.3 points surrendered per game. In terms of offense, it is accumulating 31.3 points per game, which ranks 59th.