TCU vs. Colorado Dunkel NCAA Football Picks, Predictions and Odds - Oct. 4

The TCU Horned Frogs (3-1) host the Colorado Buffaloes (2-3) on Saturday, October 4, 2025 in a matchup between Big 12 rivals at Amon G. Carter Stadium. Colorado is a 13.5-point underdog.

The Horned Frogs lost against the Arizona State Sun Devils in their last game, 27-24.

The Buffaloes' most recent game was versus the BYU Cougars, and they lost by a score of 24-21.

TCU vs. Colorado Predictions

Ahead of the upcoming game between the TCU Horned Frogs and Colorado Buffaloes, computer-calculated against-the-spread, over/under, and score predictions are below, per Dunkel Index.

• Pick ATS: Horned Frogs (- 13.5)
• Pick OU: Over (57.5)
  
• Prediction: Horned Frogs 40 - Buffaloes 22

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TCU vs. Colorado Moneylines

Snag a peek below at the most recent moneylines for the Horned Frogs-Buffaloes matchup.

• TCU Moneyline: -543
• Colorado Moneyline: +400

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TCU Betting Insights

• TCU has been the moneyline favorite just two other times so far this season, and they won both of the games.
• TCU has yet to play a game with moneyline odds of -543 or shorter.
• The Horned Frogs and their opponents have scored more than 57.5 points in three of four games this season.
• The average point total in Horned Frogs matchups this year is 58.3, 0.8 more points than this game's over/under.
• The Horned Frogs are the 46th-highest scoring team in college football this year. The Buffaloes have scored the 73rd-most points.

Colorado Betting Insights

• Colorado has been listed as the underdog three times this season and has failed to win any of those games.
• Colorado has not been a bigger underdog this season than the +400 moneyline set for this game.
• Every Colorado game this season has ended with a combined score under 57.5 points.
• Colorado's contests this season have a 48.1-point average over/under, 9.4 fewer points than this game's total.

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Key Stats for TCU vs. Colorado

• In their past two matchups, Colorado holds a split 1-1 record against TCU.
• In their past two head-to-head meetings, each team has covered one time with those contests going over the total on one occasion.
• The Horned Frogs rank 27th in total offense (454.3 yards per game) and 96th in total defense (389.3 yards allowed per game) this year.
• TCU is putting up 37.3 points per game on offense, which ranks them 30th in the FBS. Defensively, the defense ranks 55th, allowing 21.5 points per contest.
• The Buffaloes have sputtering defensively, ranking 25th-worst with 404.8 total yards allowed per game. They have been better offensively, putting up 358.2 total yards per contest (92nd-ranked).
• In terms of points scored Colorado ranks 86th in the FBS (25.8 points per game), and it is 60th on defense (22.8 points allowed per game).