Cardinals vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - Sept. 14

The St. Louis Cardinals host the San Francisco Giants to open a three-game series at Busch Stadium, with first pitch at 7:45 p.m. ET on Monday. Quinn Mathews (1-3, 4.11 ERA) gets the start for the Cardinals, who are 74-76 this season and fourth in the NL Central. Landen Roupp (9-13, 4.00 ERA) is the expected starter for the Giants, who are 62-88 and fourth in the NL West.

Sportsbooks have made the Cardinals a decent moneyline favorite (-144) at home over the Giants (+118). The over/under in this contest is 7.5.

Cardinals vs. Giants Odds, Game Time

• Game day: Monday, September 14, 2026
• Game time: 7:45 p.m. ET
• Location: St. Louis, Missouri
• Stadium: Busch Stadium
• Favorite: Cardinals (-144)
• Underdog: Giants (+118)
• Over/under: 7.5

How to Watch Cardinals vs. Giants

• TV Channel: CARD and NBCS-BA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Cardinals vs. Giants: Betting the Moneyline

• The Cardinals have won 25 of the 48 games they were favored on the moneyline this season (52.1%).
• San Francisco has been underdogs in 100 games this season and has come away with the win 37 times (37%) in those contests.
• This season St. Louis has won five of its eight games when favored by at least -144 on the moneyline.
• This year, the Giants have won 18 of 49 games when listed as at least +118 or worse on the moneyline.
• Based on this game's moneyline, the Cardinals have an implied win probability of 59%.
• The Giants have an implied victory probability of 45.9% according to the moneyline set by sportsbooks for this matchup.

Cardinals vs. Giants: Betting the Spread & Total

• The Cardinals have combined with opponents to go over the total 66 times this season for a 66-74-10 record against the over/under.
• San Francisco's games have gone over the total in 72 of its 149 chances.
• The Cardinals have gone 84-66-0 ATS this season.
• The Giants are 74-75-0 against the spread in their 149 games with a line set by sportsbooks this season.