49ers vs. Bears Week 17 Dunkel NFL Picks, Predictions and Odds

Having taken five in a row, the San Francisco 49ers (11-4) will face the Chicago Bears (11-4). The 49ers are the favorites, expected to win by at least a field goal but less than a touchdown (currently -4.5). The total for this one is set at 51.5 points.

The 49ers are averaging 26.1 points per game on offense, which ranks them ninth in the NFL. On the defensive side of the ball, they rank 11th, allowing 21.3 points per game. From an offensive perspective, the Bears are posting 25.8 points per contest (10th-ranked). They rank 19th in the NFL defensively (23.6 points given up per game).

49ers vs. Bears Odds and Game Time

• Date: Sunday, December 28, 2025
• Time: 8:20 p.m. ET
• City: Santa Clara, California
• Venue: Levi's Stadium
• Total: 51.5 points
• Spread: 49ers -4.5
• Moneyline: 49ers (-185), Bears (+154)

How to watch 49ers vs. Bears

• TV Channel: NBC/Peacock

Betting the Over/Under: 49ers vs. Bears

• The 49ers and their opponents have scored more than 51.5 points in five of 15 games this season.
• So far this season, nine of San Francisco's 15 games have hit the over.
• Bears games this season have had a combined scoring total higher than 51.5 points in three of 15 outings.
• So far this year, seven of Chicago's 15 games with a set number have gone over the point total.
• The two teams combine to score 51.9 points per game, 0.4 more points than this matchup's over/under.
• Opponents of these two teams score 44.9 points per game combined, 6.6 fewer than this matchup's total.

Betting the Spread: 49ers vs. Bears

• San Francisco has won 10 games against the spread this season, while failing to cover five times.
• San Francisco is 4-0 ATS this season when playing as at least 4.5-point favorites.
• The Bears have won 10 games against the spread this year, failing to cover five times.
• Chicago has covered the spread twice as an underdog by 4.5 points or more this year (in four opportunities).
• At home this season, the 49ers are 3-3 against the spread and 4-2 overall.
• At home, as 4.5-point favorites or greater, San Francisco is unbeaten ATS (2-0).
• On the road, the Bears are 5-3 against the spread and 5-3 overall.
• Chicago has two wins ATS (2-2) on the road as 4.5-point underdogs or more.

Betting the Moneyline: 49ers vs. Bears

• San Francisco has been favored on the moneyline 11 total times this season. They've gone 10-1 in those games.
• The Bears have been underdogs in nine games this season and won five (55.6%) of those contests.
• San Francisco has won all five games it has played as a moneyline favorite with odds of -185 or shorter.
• Chicago has entered four games this season as the underdog by +154 or more and is 2-2 in those contests.
• The 49ers have an implied moneyline win probability of 64.9% in this game.

Dunkel Prediction for 49ers vs. Bears

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