49ers vs. Panthers Week 12 Dunkel NFL Picks, Predictions and Odds

The San Francisco 49ers (7-4) are favored by seven points versus the Carolina Panthers (6-5) on November 24, 2025, starting at 8:15 p.m. ET, airing on ESPN. An over/under of 48.5 points has been established for the matchup.

On offense, the 49ers rank 15th in the NFL with 23.7 points per game. Meanwhile, they rank 14th in points allowed (352.9 points allowed per contest). The Panthers are putting up 314.3 total yards per contest on offense this season (22nd-ranked). Meanwhile, they are giving up 325.9 total yards per contest (15th-ranked).

49ers vs. Panthers Odds and Game Time

• Date: Monday, November 24, 2025
• Time: 8:15 p.m. ET
• City: Santa Clara, California
• Venue: Levi's Stadium
• Total: 48.5 points
• Spread: 49ers -7
• Moneyline: 49ers (-345), Panthers (+275)

How to watch 49ers vs. Panthers

• TV Channel: ESPN
• Live Stream: Fubo

Betting the Over/Under: 49ers vs. Panthers

• In five of 11 games this season, the 49ers and their opponents have scored more than 48.5 points.
• San Francisco games have hit the over seven out of 11 times this season.
• The Panthers have combined with their opponent to score more than 48.5 points in six of 11 games this season.
• In 2025, six Carolina games have gone over the point total.
• The teams combine to score 42.5 points per game, 6.0 fewer points than this matchup's total.
• Opponents of these teams average 45.5 points per game combined, 3.0 fewer than this matchup's total.

Betting the Spread: 49ers vs. Panthers

• San Francisco is 6-5-0 ATS this season.
• The Panthers have compiled a 7-4-0 ATS record so far this year.
• Carolina has covered the spread twice this year (2-1 ATS) when playing as at least 7-point underdogs.
• The 49ers have one win against the spread, and are 2-2 overall, at home this season.
• In away games, the Panthers are 3-3 overall and 4-2 against the spread.
• Carolina is unbeaten ATS (2-0) as 7-point underdogs or more on the road.

Betting the Moneyline: 49ers vs. Panthers

• San Francisco has a 6-1 record in games they were favored on the moneyline (winning 85.7% of those games).
• This season, the Panthers have won six out of the 10 games in which they've been the underdog.
• San Francisco has yet to play as a moneyline favorite of -345 or shorter.
• Carolina has a record of 1-1 when it is set as an underdog of +275 or more by oddsmakers this season.
• The 49ers have an implied moneyline win probability of 77.5% in this game.

Dunkel Prediction for 49ers vs. Panthers

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