Pittsburgh vs. Syracuse Dunkel NCAA Football Picks, Predictions and Odds - Oct. 18

A pair of the nation's most prolific passing offenses square off when the Pittsburgh Panthers (4-2) bring college football's 11th-ranked passing offense into a matchup with the Syracuse Orange (3-3), who have the No. 6 passing offense, on Saturday, October 18, 2025. The Panthers are 9.5-point favorites.

Facing the Florida State Seminoles in their most recent contest, the Panthers won 34-31.

In their most recent contest, the Orange lost against the SMU Mustangs, 31-18.

Pittsburgh vs. Syracuse Predictions

For the upcoming contest between the Pittsburgh Panthers and Syracuse Orange, computer-calculated against-the-spread, over/under, and score predictions are below, sourced from Dunkel Index.

• Pick ATS: Orange (+ 9.5)
• Pick OU: Over (54.5)
  
• Prediction: Panthers 34 - Orange 26

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Pittsburgh vs. Syracuse Moneylines

Grab a look below at the latest moneylines for the Panthers-Orange game.

• Pittsburgh Moneyline: -369
• Syracuse Moneyline: +289

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Pittsburgh Betting Insights

• Pittsburgh has won three of the four games it was favored on the moneyline this season (75%).
• Pittsburgh has played as a moneyline favorite of -369 or shorter in only two games this season, and it won both.
• Every game the Panthers have played this season has gone over 54.5 total points.
• The Panthers have an average total of 54.9 in their outings this year, 0.4 more points than this game's over/under.
• The Panthers score the 15th-most points in college football this season, while the Orange's offense racks up the 71st-most.

Syracuse Betting Insights

• Syracuse has entered the game as an underdog four times this season and won once.
• Syracuse has a record of 1-2 when it is set as an underdog of +289 or more by oddsmakers this season.
• Syracuse has played three games this season that ended with a combined score higher than 54.5 points.
• The average over/under for Syracuse's contests this season is 57.5, 3.0 more points than this game's point total.

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Key Stats for Pittsburgh vs. Syracuse

• In their past four head-to-head contests, Pittsburgh has won against Syracuse three times.
• In those contests versus Syracuse, the Panthers have covered three times while eclipsing the point total on one occasion.
• The Panthers are compiling 431.8 yards per game on offense (37th in the FBS), and they rank 32nd on defense with 313.7 yards allowed per game.
• Pittsburgh ranks 52nd in scoring defense this year (21.5 points allowed per game), but has been shining on the other side of the ball, ranking 14th-best in the FBS with 39.8 points per game.
• The Orange's defense has been a bottom-25 unit in total defense this season, surrendering 448.8 total yards per game, which ranks 10th-worst. On offense, they rank 36th with 432.3 total yards per contest.
• Syracuse has not been getting things done on defense, ranking 23rd-worst with 29.8 points allowed per game. It has been better on the other side of the ball, putting up 29 points per contest (69th-ranked).