Cardinals vs. Reds Dunkel MLB Picks, Predictions and Prop Bets - June 5

The St. Louis Cardinals host the Cincinnati Reds to open a three-game series at Busch Stadium, with first pitch at 8:15 p.m. ET on Friday. Kyle Leahy (5-3, 4.25 ERA) gets the start for the Cardinals, who are 32-28 this season and third in the NL Central. Brady Singer (2-5, 6.18 ERA) is expected to start for the Reds, who are 31-30 and fifth in the NL Central.

Bookmakers have made the Cardinals a decent moneyline favorite (-142) at home over the Reds (+119). The game has an over/under set at 9 runs.

Cardinals vs. Reds Odds, Game Time

• Game day: Friday, June 5, 2026
• Game time: 8:15 p.m. ET
• Location: St. Louis, Missouri
• Stadium: Busch Stadium
• Favorite: Cardinals (-142)
• Underdog: Reds (+119)
• Over/under: 9

How to Watch Cardinals vs. Reds

• TV Channel: CARD and CINR
• Live Stream: Fubo (Watch Now!)

Bet now on FanDuel Sportsbook!

Cardinals vs. Reds: Betting the Moneyline

• The Cardinals have won six of the 10 games they were the moneyline favorite this season (60%).
• Cincinnati has won in 19, or 48.7%, of the 39 contests it has been named as odds-on underdogs in this year.
• St. Louis has not entered a game this season as bigger favorites on the moneyline than the -142 odds on them winning this game.
• This season, the Reds have been victorious four times in 12 chances when named as an underdog of at least +119 or worse on the moneyline.
• Based on this contest's moneyline, the Cardinals have an implied win probability of 58.7%.
• Sportsbooks have implied with the moneyline set for this matchup that the Reds have a 45.7% chance of pulling out a win.

Cardinals vs. Reds: Betting the Spread & Total

• The Cardinals have played in 60 games with set over/under, and have combined with opponents to go over the total 23 times (23-31-6).
• Cincinnati and its opponents have hit the over in 37 of its 61 games with a total this season.
• The Cardinals have put together a 36-24-0 record ATS this season (covering 60% of the time).
• The Reds are 34-27-0 against the spread in their 61 games with a line set by sportsbooks this season.